Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1).

Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1). Research Abstract Details 

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Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1). Abstract Text:

The synthesis of pregnancy-specific beta-1-glycoprotein (SP1) was studied in human syncytiotrophoblast cultures from first trimester placentas. Incorporation of 35S-methionine into SP1 was demonstrated by immunoprecipitation and polyacrylamide gel electrophoresis. In double diffusion the precipitation line of neosynthesized SP1 gave a reaction of complete immunological identity with maternal serum SP1. By indirect immunofluorescence intracellular SP1 was localised in the perinuclear region of the cells. The average rate of SP1 release into culture fluid was 600 ng/mg protein in 24 hours. On a molar basis the release of SP1 was 10 times less than that of human chorionic gonadotrophin (hCG). Our results demonstrate, for the first time, that cultured human syncytiotrophoblasts synthesis SP1 immunologically indistinguishable from placental SP1.

Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1). Publishing Authors By Initials

For similar cells: trophoblasts research abstracts see: cells: trophoblasts research

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Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 89

Page Numbers: 139-44

Journal Abbreviation:

ISSN: 0304-1328

DAY: 26

MONTH: Apr

YEAR: 1981

Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1). Information

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LANGUAGE: eng

NlmUniqueID: 7508469

Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1). Keywords Mesh Terms:

KEYWORDS: Trophoblasts

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1). Information

Substance Name: Pregnancy-Specific beta 1-Glycoproteins

Registry Number: 0

Grant and Affiliation Information for Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1).

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Scand [C

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