Culture-negative Bartonella endocarditis in a patient with renal failure: the value of molecular methods in diagnosis.

Culture-negative Bartonella endocarditis in a patient with renal failure: the value of molecular methods in diagnosis. Research Abstract Details 

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Culture-negative Bartonella endocarditis in a patient with renal failure: the value of molecular methods in diagnosis. Abstract Text:

S Todd,J Xu,B C Millar,J E Moore,M Crowe,D Raoult,T Harrison,C Hill,J Douglas,S Todd,J Xu,B C Millar,J E Moore,M Crowe,D Raoult,T Harrison,C Hill,J Douglas,

Members of the genus Bartonella are increasingly recognised as a cause of culture-negative endocarditis, particularly in those patients with underlying risk factors (e.g., homelessness and alcoholism (B. quintana) or valvulopathy and cat ownership (B. henselae). The aortic and mitral-valves are most commonly involved. Here, a case is reported of culture-negative right-sided endocarditis, without any of the above risk factors, due to Bartonella sp. in a 69-year-old man who presented with acute renal failure. The diagnosis was made using a broad-range 16S rRNA polymerase chain reaction (PCR) technique and direct automated sequencing on a peripheral blood sample, which was subsequently confirmed serologically. A review of the literature on Bartonella endocarditis is also presented. Molecular laboratory methods using peripheral blood or blood cultures may be very useful in the diagnosis of causal agents in culture-negative endocarditis and add further support to the recently inclusion of molecular (PCR) diagnosis, as a major Duke's criterion, for the diagnosis of infective endocarditis.

Culture-negative Bartonella endocarditis in a patient with renal failure: the value of molecular methods in diagnosis. Publishing Authors By Initials

S Todd,J Xu,BC Millar,JE Moore,M Crowe,D Raoult,T Harrison,C Hill,J Douglas,S Todd,J Xu,BC Millar,JE Moore,M Crowe,D Raoult,T Harrison,C Hill,J Douglas,

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Culture-negative Bartonella endocarditis in a patient with renal failure: the value of molecular methods in diagnosis. Journal Published:

PUBLICATION TYPE: Review

Journal: British journal of biomedical science

VOLUME: 61

Page Numbers: 190-3

Journal Abbreviation: Br. J. Biomed. Sci.

ISSN: 0967-4845

DAY: 14

MONTH: 01

YEAR: 2004

Culture-negative Bartonella endocarditis in a patient with renal failure: the value of molecular methods in diagnosis. Information

Number of References: 27

LANGUAGE: eng

NlmUniqueID: 9309208

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Grant and Affiliation Information for Culture-negative Bartonella endocarditis in a patient with renal failure: the value of molecular methods in diagnosis.

AFFILIATION: Directorate of Nephrology, Belfast City Hospital, Belfast, Northern Ireland.

Country: England

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MEDLINETA: Br J Biomed Sci

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