CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH).

CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH). Research Abstract Details 

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CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH). Abstract Text:

Kenji Dohi,Beth Ripley,Nobuhiro Fujiki,Hirokazu Ohtaki,Takefumi Yamamoto,Yoko Goto,Tomoya Nakamachi,Seiji Shioda,Tohru Aruga,Seiji Nishino,

Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of both the feeding behavior neuroendocrine functions and sleep-wakefulness cycle. Recent studies have suggested that the orexin system may also be involved in neuronal damage in the clinical setting and animal experiments. The aim of this study was to examine the role of the hypothalamic orexin-A/hypocretin-1 system in patients with intracerebral hemorrhage (ICH). The CSF orexin-A/hypocretin-1 levels were measured in 11 ICH patients. CSF orexin-A/hypocretin-1 levels were low in ICH patients during the 13 days following the ICH event. The mean CSF orexin-A/hypocretin-1 levels were 61.1+/-22.3 (S.D.) pg/ml (range 27.5-106.9 pg/ml).The decreasing in the CSF orexin-A/hypocretin-1 levels was not related to the severity of ICH. The CSF orexin-A/hypocretin-1 levels were lower in the thalamic hemorrhage patients than those in other patients (48.5+/-23.3 pg/ml vs. 65.2+/-21.2 pg/ml; p=0.03.) These data indicate that orexin-A/hypocretin-1 may therefore play an important role in the various physiological responses including sleep, feeding, and the overall metabolism in ICH patients.

CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH). Publishing Authors By Initials

K Dohi,B Ripley,N Fujiki,H Ohtaki,T Yamamoto,Y Goto,T Nakamachi,S Shioda,T Aruga,S Nishino,

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CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Regulatory peptides

VOLUME: 145

Page Numbers: 60-4

Journal Abbreviation: Regul. Pept.

ISSN: 0167-0115

DAY: 22

MONTH: 08

YEAR: 2007

CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH). Information

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LANGUAGE: eng

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AFFILIATION: Showa University, Department of Emergency and Critical Care Medicine, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.

Country: Netherlands

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MEDLINETA: Regul Pept

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