CSF beta-EP in headache and depression.

CSF beta-EP in headache and depression. Research Abstract Details 

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CSF beta-EP in headache and depression. Abstract Text:

G Nappi,F Facchinetti,E Martignoni,F Petraglia,G Bono,A R Genazzani,

Cerebrospinal fluid (CSF) levels of beta-endorphin (beta-EP) were measured in 9 migraineurs with interparoxysmal headache (MIH), in 13 patients with major depression in an active phase (5 suffered from MIH), and in 16 age-matched controls. beta-EP was measured by specific RIA after gel-chromatography. While beta-EP levels of depressed patients (58.5 +/- 21.0 fmol/ml, M +/- SD) were similar to those of controls (65.8 +/- 26.6), those of migraineurs (15.0 +/- 11.1) were significantly reduced (p less than 0.01). In depressed patients also suffering from MIH, beta-EP concentrations (22.8 +/- 7.2, p less than 0.05) were half those reported in depressed patients without pain problems. The reduced CSF beta-EP levels in patients whose headache and depression coexist support the notion that this neuropeptide is concerned with chronic pain, independently of the affective state.

CSF beta-EP in headache and depression. Publishing Authors By Initials

G Nappi,F Facchinetti,E Martignoni,F Petraglia,G Bono,AR Genazzani,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pro-opiomelanocortin: beta-endorphin research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pro-opiomelanocortin: beta-endorphin research

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CSF beta-EP in headache and depression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cephalalgia : an international journal of headache

VOLUME: 5

Page Numbers: 99-101

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Jun

YEAR: 1985

CSF beta-EP in headache and depression. Information

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LANGUAGE: eng

NlmUniqueID: 8200710

CSF beta-EP in headache and depression. Keywords Mesh Terms:

KEYWORDS: beta-Endorphin

MESH TERMS: cerebrospinal fluid

Chemical & Substance for Abstract: CSF beta-EP in headache and depression. Information

Substance Name: beta-Endorphin

Registry Number: 60617-12-1

Grant and Affiliation Information for CSF beta-EP in headache and depression.

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Country: NORWAY

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MEDLINETA: Cephalalgia

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