Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling.

Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Research Abstract Details 

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Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Abstract Text:

Hua Yuan,Spencer Anderson,Shinji Masuda,Vladimira Dragnea,Keith Moffat,Carl Bauer,

Crystal structures of the Synechocystis BLUF phototaxis photoreceptor Slr1694 have been determined in two crystal forms, a monoclinic form at 1.8 A resolution and an orthorhombic form at 2.1 A resolution. In both forms, the photoreceptor is comprised of two pentamer rings stacked face to face. Twenty total subunits in the two asymmetric units of these crystal forms display three distinct tertiary structures that differ in the length of the fifth beta-strand and in the orientation of Trp91, a conserved Trp residue near the FMN chromophore. Fluorescence spectroscopic analysis on Slr1694 in solution is consistent with motion of Trp91 from a hydrophobic environment in the dark state to a more hydrophilic environment in the light-excited state. Mutational analysis indicates that movement of Trp91 is dependent on the occupancy of the hydrophobic Trp binding pocket with a nearby Met. These different tertiary structures may be associated with absorption changes in the blue region of the spectrum.

Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Publishing Authors By Initials

H Yuan,S Anderson,S Masuda,V Dragnea,K Moffat,C Bauer,

For similar amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tryptophan research abstracts see: amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tryptophan research

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Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemistry

VOLUME: 45

Page Numbers: 12687-94

Journal Abbreviation: Biochemistry

ISSN: 0006-2960

DAY: 24

MONTH: Oct

YEAR: 2006

Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370623

Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Keywords Mesh Terms:

KEYWORDS: Tryptophan

MESH TERMS: chemistry

Chemical & Substance for Abstract: Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling. Information

Substance Name: Tryptophan

Registry Number: 73-22-3

Grant and Affiliation Information for Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling.

AFFILIATION: Department of Biology, Indiana University, Bloomington, Indiana 47405, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR07707

ACRONYM: RR

MEDLINETA: Biochemistry

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