Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis.

Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis. Research Abstract Details 

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Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis. Abstract Text:

Hitoshi Katada,Hidetake Seino,Yasushi Mizobe,Jun Sumaoka,Makoto Komiyama,

The structures of Ce(4+) complexes that are active for DNA hydrolysis were determined for the first time by X-ray crystallography. The crystals were prepared from a 1:2 mixture of Ce(NH(4))(2)(NO(3))(6) and dipicolinic acid (2,6-pyridinedicarboxylic acid). Depending on the recrystallization conditions, three types of crystals were obtained. Some of the Ce(4+) ions in these complexes have enough coordinated water molecules that can directly and indirectly participate in the catalysis. The distances between the Ce(4+) and the dipicolinate ligand are considerably shorter than those in the corresponding La(3+) and Ce(3+) complexes. On the other hand, the distances between the Ce(4+) and its coordinated water are similar to those for the La(3+) and Ce(3+) complexes. In a proposed mechanism of DNA hydrolysis, the scissile phosphodiester linkage is notably activated by coordination to Ce(4+) and attacked by the Ce(4+)-bound hydroxide. The process is further assisted by acid catalysis of Ce(4+)-bound water.

Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis. Publishing Authors By Initials

H Katada,H Seino,Y Mizobe,J Sumaoka,M Komiyama,

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Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biological inorganic chemistry : JBIC :

VOLUME: 13

Page Numbers: 249-55

Journal Abbreviation: J. Biol. Inorg. Chem.

ISSN: 0949-8257

DAY: 7

MONTH: 11

YEAR: 2007

Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Crystal structure of Ce(IV)/dipicolinate complex as catalyst for DNA hydrolysis.

AFFILIATION: Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan, komiyama@mkomi.rcast.u-tokyo.ac.jp.

Country: Germany

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MEDLINETA: J Biol Inorg Chem

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