Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Abstract Text:

E F Lee,P E Czabotar,B J Smith,K Deshayes,K Zobel,P M Colman,W D Fairlie,E F Lee,P E Czabotar,B J Smith,K Deshayes,K Zobel,P M Colman,W D Fairlie,

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Publishing Authors By Initials

EF Lee,PE Czabotar,BJ Smith,K Deshayes,K Zobel,PM Colman,WD Fairlie,EF Lee,PE Czabotar,BJ Smith,K Deshayes,K Zobel,PM Colman,WD Fairlie,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Journal Published:

PUBLICATION TYPE: Letter

Journal: Cell death and differentiation

VOLUME: 14

Page Numbers: 1711-3

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 15

MONTH: 06

YEAR: 2007

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9437445

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.

AFFILIATION:

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Death Differ

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family Related Publications

• A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
• A refined agonist pharmacophore for protease activated receptor 2.
• Amyloid peptides and proteins in review.
• Cell phenotype as a target of drug therapy in chronic inflammatory diseases.
• Chronic gastritis as a source of gross hemorrhage; a report and discussion of four cases.
• Conformationally homogeneous cyclic tetrapeptides: useful new three-dimensional scaffolds.
• Consecutive cyclic pentapeptide modules form short alpha-helices that are very stable to water and denaturants.
• Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.
• Current status of short synthetic peptides as vaccines.
• Cyclooligomerization of a helix-bearing template into macrocycles bearing multiple helices.
• EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.
• Function, structure and therapeutic potential of complement C5a receptors.
• Hepta and octapeptide agonists of protease-activated receptor 2.
• Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)3His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation.
• New cysteine derivatives with antiproliferative activity on melanoma cells.
• New evidence of childhood leukaemias near nuclear power stations.
• Potent antimalarial activity of histone deacetylase inhibitor analogues.
• Profiling the enzymatic properties and inhibition of human complement factor B.
• Protease inhibitors in the clinic.
• Unexpected photolytic decomposition of alkyl azides under mild conditions.