Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.

Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Research Abstract Details 

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Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Abstract Text:

Dingzhi Wang,Haibin Wang,Yong Guo,Wei Ning,Sharada Katkuri,Walter Wahli,Beatrice Desvergne,Sudhansu K Dey,Raymond N DuBois,

Peroxisome proliferator-activated receptor (PPAR) delta is a member of the nuclear hormone receptor superfamily. PPARdelta may ameliorate metabolic diseases such as obesity and diabetes. However, PPARdelta's role in colorectal carcinogenesis remains controversial. Here, we present genetic and pharmacologic evidence demonstrating that deletion of PPARdelta decreases intestinal adenoma growth in Apc(Min/+) mice and inhibits tumor-promoting effects of a PPARdelta agonist GW501516. More importantly, we found that activation of PPARdelta up-regulated VEGF in colon carcinoma cells. VEGF directly promotes colon tumor epithelial cell survival through activation of PI3K-Akt signaling. These results not only highlight concerns about the use of PPARdelta agonists for treatment of metabolic disorders in patients who are at high risk for colorectal cancer, but also support the rationale for developing PPARdelta antagonists for prevention and/or treatment of cancer.

Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Publishing Authors By Initials

D Wang,H Wang,Y Guo,W Ning,S Katkuri,W Wahli,B Desvergne,SK Dey,RN DuBois,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 19069-74

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 5

MONTH: 12

YEAR: 2006

Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: metabolism

Chemical & Substance for Abstract: Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Information

Substance Name: Proto-Oncogene Proteins c-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.

AFFILIATION: Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue, Nashville, TN 37232-2279, USA.

Country: United States

AGENCY: United States NICHD

GRANT: R37 HD 12304

ACRONYM: HD

MEDLINETA: Proc Natl Acad Sci U S A

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