Cross validation of multiple methods for measuring pyrethroid and pyrethrum insecticide metabolites in human urine.

Cross validation of multiple methods for measuring pyrethroid and pyrethrum insecticide metabolites in human urine. Research Abstract Details 

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Cross validation of multiple methods for measuring pyrethroid and pyrethrum insecticide metabolites in human urine. Abstract Text:

Dana B Barr,Gabriele Leng,Edith Berger-Preiss,Hans-Wolfgang Hoppe,Gayanga Weerasekera,Wolfgang Gries,Susanne Gerling,Jose Perez,Kimberly Smith,Larry L Needham, Angerer,Dana B Barr,Gabriele Leng,Edith Berger-Preiss,Hans-Wolfgang Hoppe,Gayanga Weerasekera,Wolfgang Gries,Susanne Gerling,Jose Perez,Kimberly Smith,Larry L Needham, Angerer,

The objective of our study was to compare three vastly different analytical methods for measuring urinary metabolites of pyrethroid and pyrethrum insecticides to determine whether they could produce comparable data and to determine if similar analytical characteristics of the methods could be obtained by a secondary laboratory. This study was conducted as a part of a series of validation studies undertaken by the German Research Foundation's Committee on the Standardization of Analytical Methods for Occupational and Environmental Medicine. We compared methods using different sample preparation methods (liquid-liquid extraction and solid-phase extraction with and without chemical derivatization) and different analytical detection methods (gas chromatography-mass spectrometry (single quadrupole), gas chromatography-high resolution mass spectrometry (magnetic sector) in both electron impact ionization and negative chemical ionization modes, and high-performance liquid chromatography-tandem mass spectrometry (triple quadrupole) with electrospray ionization). Our cross validation proved that similar analytical characteristics could be obtained with any combination of sample preparation/analytical detection method and that all methods produced comparable analytical results on unknown urine samples.

Cross validation of multiple methods for measuring pyrethroid and pyrethrum insecticide metabolites in human urine. Publishing Authors By Initials

DB Barr,G Leng,E Berger-Preiss,HW Hoppe,G Weerasekera,W Gries,S Gerling,J Perez,K Smith,LL Needham,J Angerer,DB Barr,G Leng,E Berger-Preiss,HW Hoppe,G Weerasekera,W Gries,S Gerling,J Perez,K Smith,LL Needham,J Angerer,

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Cross validation of multiple methods for measuring pyrethroid and pyrethrum insecticide metabolites in human urine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Analytical and bioanalytical chemistry

VOLUME: 389

Page Numbers: 811-8

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ISSN: 1618-2642

DAY: 9

MONTH: 09

YEAR: 2007

Cross validation of multiple methods for measuring pyrethroid and pyrethrum insecticide metabolites in human urine. Information

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LANGUAGE: eng

NlmUniqueID: 101134327

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AFFILIATION: National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA. dbarr@cdc.gov

Country: Germany

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MEDLINETA: Anal Bioanal Chem

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