Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells.

Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells. Abstract Text:

Ji-Jie Pang,Fan Gao,Samuel M Wu,

It has been widely accepted that ON and OFF channels in the visual system are segregated with little cross-communication, except for the mammalian rod bipolar cell-AII amacrine cell-ganglion cell pathway. Here, we show that in the tiger salamander retina the light responses of a subpopulation of ON-OFF ganglion cells are mediated by crossing the ON and OFF bipolar cell pathways. Although the majority of ON-OFF ganglion cells (type I cells) receive direct excitatory inputs from depolarizing and hyperpolarizing bipolar cells (DBCs and HBCs), about 5% (type II cells) receive indirect excitatory inputs from DBCs and 20% (type III cells) receive indirect excitatory inputs from HBCs. These indirect bipolar cell inputs are likely to be mediated by a subpopulation of amacrine cells that exhibit transient hyperpolarizing light responses (AC(H)s) and make GABAergic/glycinergic synapses on DBC or HBC axon terminals. GABA and glycine receptor antagonists enhanced the ON and OFF excitatory cation current (DeltaI(C)) in type I ganglion cells, but completely suppressed the ON DeltaI(C) mediated by DBCs in type II cells and the OFF DeltaI(C) mediated by HBCs in types III cells. Dendrites of type I cells ramify in both sublamina A and B, type II cells exclusively in sublamina A, and type III cells exclusively in sublamina B of the inner plexiform layer. These results demonstrate that indirect, amacrine cell-mediated bipolar cell-ganglion cell synaptic pathways exist in a non-mammalian retina, and that bidirectional cross-talk between ON and OFF channels is present in the vertebrate retina.

Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells. Publishing Authors By Initials

JJ Pang,F Gao,SM Wu,

For similar nervous system: neural pathways: afferent pathways: visual pathways research abstracts see: nervous system: neural pathways: afferent pathways: visual pathways research

PUBMED ID PMID:

MEDLINE DATE:

Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Vision research

VOLUME: 47

Page Numbers: 384-92

Journal Abbreviation: Vision Res.

ISSN: 0042-6989

DAY: 7

MONTH: 11

YEAR: 2006

Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 417402

Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells. Keywords Mesh Terms:

KEYWORDS: Visual Pathways

MESH TERMS: physiology

Chemical & Substance for Abstract: Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells. Information

Substance Name: Receptors, GABA

Registry Number: 0

Grant and Affiliation Information for Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells.

AFFILIATION: Cullen Eye Institute, Baylor College of Medicine, One Baylor Plaza, NC-205, Houston, TX 77030, USA.

Country: England

AGENCY: United States NEI

GRANT: EY 04446

ACRONYM: EY

MEDLINETA: Vision Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cross-talk between ON and OFF channels in the salamander retina: indirect bipolar cell inputs to ON-OFF ganglion cells Related Publications

• Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region.
• Clinical analysis of 4 cases of juvenile granulosa cell tumor of the ovary.
• Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates.
• Effects of As(2)O(3) on BCR-ABL protein level and signal transduction in CML cells.
• Etiological analysis on the ocular fungal infection.
• Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow.
• Monocyte chemoattractant protein-1 mRNA in human intracranial aneurysm walls.
• Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms.
• Significance of HER-2/neu expression in ovarian epithelial tumours.
• Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop.
• Study on some mechanism of leucite microcrystallization to reinforce dental glass ceramics.
• The clinical study of lateral orbitotomy.
• The expression, characterization and roles of macrophage colony-stimulating factor receptor in human leukemia cell lines.
• Thermal hyperalgesic effects induced by intracerebroventricular injection of interleukin-1beta in rats.
• [Arsenic exposure of residents in areas near Shimen arsenic mine]
• [Clinical study of treatment with continuous renal replacement therapy on severe hepatitis with hepatic encephalopathy]
• [Content of metals in different diameter airborne particles and effect on micronuclei formation in human lymphocytes]
• [Detection of monosomy 7 or 7q- in cases of myelodysplastic syndrome]
• [Determination of triptolide in tripterygium preparations by gradient high performance liquid chromatography]
• [Discussion on the concept problem of the specific retention volume in gas chromatography]
• [Effect of recombinant human bone morphogenetic protein-2 on the expression of osteopontin in human periodontal ligament cells]
• [Liver sinusoidal endothelial cell damage during normothermic ischemia and reperfusion of rat]
• [Oral combination chemotherapy of 5'-deoxy-5-fluorouridine (furtulon) and cyclophosphamide for advanced breast cancer]
• [Pathological features of atrial isomerism and its diagnosis by computed tomography]
• [Preliminary study on the molecular mechanism of K562 cell apoptosis induced by As2S2]
• [Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease]
• [Screening and identification of egg mimotope of Schistosoma japonicum]
• [Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein]
• [Study of acute physiology and chronic health evaluation III and multiple organ dysfunction syndrome score in evaluating severity of intensive care units patient]
• [Study on hepatic-protective effect of "yinzhihuang" granula]