Cross-talk between bone morphogenic proteins and estrogen receptor signaling.

Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Abstract Text:

Tetsuya Yamamoto,Fahri Saatcioglu,Tadashi Matsuda,

Bone morphogenic proteins (BMPs) play central roles in differentiation, development, and physiological tissue remodeling. Estrogens have key roles in a variety of biological events, such as the development and maintenance of numerous target tissues. Previous studies demonstrated that estrogens suppress BMP functions by repressing BMP gene expression. Here we present a novel mechanism for the inhibitory effect of estrogens on BMP function. BMP-2-induced activation of Sma and Mad (mothers against decapentaplegic)-related protein (Smad) activity and BMP-2-mediated gene expression were suppressed by 17beta-E2 in breast cancer cells and mesangial cells. E2-mediated inhibition of Smad activation was reversed by tamoxifen, an ER antagonist. We provide evidence that the inhibitory action of ER on Smad activity was due to direct physical interactions between Smads and ER, which represents a novel mechanism for the cross-talk between BMP and ER signaling pathways.

Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Publishing Authors By Initials

T Yamamoto,F Saatcioglu,T Matsuda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endocrinology

VOLUME: 143

Page Numbers: 2635-42

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 19

MONTH: Jul

YEAR: 2002

Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: Cross-talk between bone morphogenic proteins and estrogen receptor signaling. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for Cross-talk between bone morphogenic proteins and estrogen receptor signaling.

AFFILIATION: Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku Kita 12 Nishi 6, Sapporo 060-0812, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Endocrinology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cross-talk between bone morphogenic proteins and estrogen receptor signaling Related Publications

• An assessment of the attitudes of potential caregivers toward the abuse of elderly persons with and without dementia.
• Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug "Shin-i" (Flos Magnoliae).
• Biosynthetic diversity in plant triterpene cyclization.
• Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana.
• Blood purification for hypercytokinemia.
• Cloning, sequencing and characterization of a urease gene operon from urease-positive thermophilic Campylobacter (UPTC).
• Cloning, sequencing and molecular characterisation of a cryptic plasmid from a urease-positive thermophilic Campylobacter (UPTC) isolate.
• Comparative chromosome painting map between two Ryukyu spiny rat species, Tokudaia osimensis and Tokudaia tokunoshimensis (Muridae, Rodentia).
• Comparison of the Z and W sex chromosomal architectures in elegant crested tinamou (Eudromia elegans) and ostrich (Struthio camelus) and the process of sex chromosome differentiation in palaeognathous birds.
• Comparison of time trends in lung cancer incidence (1973 97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vols IV VIII.
• Cross-talk between bone morphogenic proteins and estrogen receptor signaling.
• Distribution and immunohistochemical localization of GDNF protein in selected neural and non-neural tissues of rats during development and changes in unilateral 6-hydroxydopamine lesions.
• Distribution of prosaposin in the rat nervous system.
• Effects of repeated praziquantel treatment on schistosomiasis mekongi morbidity as detected by ultrasonography.
• Elastomeric surgical sealant for hemostasis of cardiovascular anastomosis under full heparinization.
• Evaluation of brain perfusion SPECT using an easy Z-score imaging system (eZIS) as an adjunct to early-diagnosis of neurodegenerative diseases.
• Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.
• Graft replacement and muscle wrap for infected aneurysm of thoracic aorta.
• Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2.
• Influence of the 70% methanolic extract from red ginseng on the lysosome of tumor cells and on the cytocidal effect of mitomycin c1.
• Metachromasy of crystal violet in the presence of poly(alpha-L-glutamic acid) and the bound-dye spectra determined by the principal/component-analysis method.
• Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice.
• Pegylated TNF-alpha receptor does not prevent acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model.
• Phenotypic characterisation of flagellin and flagella of urease-positive thermophilic campylobacters.
• Prediction of left atrial appendage thrombi in non-valvular atrial fibrillation.
• Relationship between financial competence and cognitive function in patients with schizophrenia.
• Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice.
• Simulation algorithm for the coupling of the left ventricular mechanical model with arbitrary circulation model.
• The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.
• Voltage-dependent capacitance as a probe for albumin adsorption onto a solid surface.