Critical role of dendritic cells in mouse mammary tumor virus in vivo infection.

Critical role of dendritic cells in mouse mammary tumor virus in vivo infection. Research Abstract Details 

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Critical role of dendritic cells in mouse mammary tumor virus in vivo infection. Abstract Text:

Maria Cecilia Courreges,Dalia Burzyn,Irene Nepomnaschy,Isabel Piazzon,Susan R Ross,

Mouse mammary tumor virus (MMTV) is a milk-transmitted betaretrovirus that causes mammary tumors in mice. Although mammary epithelial cells are the ultimate targets of MMTV, the virus utilizes components of the host immune system to establish infection. Previous studies indicated that dendritic cells play a role in MMTV infection. Here we show that dendritic cells are the first cells to be infected by MMTV in vivo and that they are capable of producing infectious virus that can be transmitted to other cell types. Moreover, upon contact with the virus, dendritic cells became more mature and migrated in response to the chemokine macrophage inflammatory protein 3beta. Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo.

Critical role of dendritic cells in mouse mammary tumor virus in vivo infection. Publishing Authors By Initials

MC Courreges,D Burzyn,I Nepomnaschy,I Piazzon,SR Ross,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

PUBMED ID PMID:

MEDLINE DATE:

Critical role of dendritic cells in mouse mammary tumor virus in vivo infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 3769-77

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 31

MONTH: 01

YEAR: 2007

Critical role of dendritic cells in mouse mammary tumor virus in vivo infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Critical role of dendritic cells in mouse mammary tumor virus in vivo infection. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: virology

Chemical & Substance for Abstract: Critical role of dendritic cells in mouse mammary tumor virus in vivo infection. Information

Substance Name: Macrophage Inflammatory Proteins

Registry Number: 0

Grant and Affiliation Information for Critical role of dendritic cells in mouse mammary tumor virus in vivo infection.

AFFILIATION: Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, 313 BRBII/III, 421 Curie Blvd., Philadelphia, PA 19104-6142, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R21AI059625

ACRONYM: AI

MEDLINETA: J Virol

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