[Criteria for the establishment of limits for antibacterial chemotherapy]

[Criteria for the establishment of limits for antibacterial chemotherapy] Research Abstract Details 

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[Criteria for the establishment of limits for antibacterial chemotherapy] Abstract Text:

G Linzenmeier,

The safety of patients asks for stringent standards when fixing limit values of the minimal inhibition concentration (MIC) in mg/l. It should be possible to recognize resistant bacterial strains with a low error on the basis of the recommendations of the bacteriological laboratory which are eventually important for therapy. Attention is drawn to the use of recognized methods such as DIN 58940 and 58944 and the participation in interlaboratory studies. Only such bacteria should be interpreted as "susceptible" whose MIC's are reliably below or, which is even better, much below the generally recognized average blood and tissue levels. Thus the break-points for the rating "susceptible" must be within the range of low variation. As a result, a few strains more would come within the "moderately susceptible" range. This would not exclude them from being selected if chemotherapy is performed with a correspondingly higher dosage (provided it is tolerated). Information on the chances of a success of therapy is improved in this way. A generous interpretation of pharmacokinetic data will in the end be more to the patient's detriment. In addition, there are numerous factors determining success or failure of therapy which cannot be established in vitro so that it is advisable to fix laboratory parameters in a stringent manner like that applied in the annexes (evaluation steps) to parts 3 and 4 of DIN 58940.

[Criteria for the establishment of limits for antibacterial chemotherapy] Publishing Authors By Initials

G Linzenmeier,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research

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[Criteria for the establishment of limits for antibacterial chemotherapy] Journal Published:

PUBLICATION TYPE: Review

Journal: Zentralblatt für Bakteriologie, Mikrobiologie, und

VOLUME: 270

Page Numbers: 138-44

Journal Abbreviation:

ISSN: 0176-6724

DAY: 12

MONTH: Nov

YEAR: 1988

[Criteria for the establishment of limits for antibacterial chemotherapy] Information

Number of References: 31

LANGUAGE: ger

NlmUniqueID: 8403032

[Criteria for the establishment of limits for antibacterial chemotherapy] Keywords Mesh Terms:

KEYWORDS: Humans

MESH TERMS: drug therapy

Chemical & Substance for Abstract: [Criteria for the establishment of limits for antibacterial chemotherapy] Information

Substance Name: Anti-Bacterial Agents

Registry Number: 0

Grant and Affiliation Information for [Criteria for the establishment of limits for antibacterial chemotherapy]

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Country: GERMANY, WEST

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MEDLINETA: Zentralbl Bakteriol Mikrobiol

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