CRF receptors in the rodent and human cardiovascular systems: species differences.

CRF receptors in the rodent and human cardiovascular systems: species differences. Research Abstract Details 

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CRF receptors in the rodent and human cardiovascular systems: species differences. Abstract Text:

Beatrice Waser,Ruth Rehmann,Jean Rivier,Wylie Vale,Jean Claude Reubi,Beatrice Waser,Ruth Rehmann,Jean Rivier,Wylie Vale,Jean Claude Reubi,

CRF has powerful receptor-mediated cardiovascular actions. To evaluate the precise distribution of CRF receptors, in vitro CRF receptor autoradiography with (125)I-[Tyr(0), Glu(1), Nle(17)]-sauvagine or [(125)I]-antisauvagine-30 was performed in the rodent and human cardiovascular system. An extremely high density of CRF(2) receptors was detected with both tracers in vessels of rodent lung, intestine, pancreas, mesenterium, kidney, urinary bladder, testis, heart, brain, and in heart muscle. In humans, CRF(2) receptors were detected with (125)I- antisauvagine-30 at low levels in vessels of kidneys, intestine, urinary bladder, testis, heart and in heart muscle, while only heart vessels were detected with (125)I-[Tyr(0), Glu(1), Nle(17)]-sauvagine. This is the first extensive morphological study reporting the extremely wide distribution of CRF(2) receptors in the rodent cardiovascular system and a more limited expression in man, suggesting a species-selective CRF receptor expression.

CRF receptors in the rodent and human cardiovascular systems: species differences. Publishing Authors By Initials

B Waser,R Rehmann,J Rivier,W Vale,JC Reubi,B Waser,R Rehmann,J Rivier,W Vale,JC Reubi,

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CRF receptors in the rodent and human cardiovascular systems: species differences. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Peptides

VOLUME: 27

Page Numbers: 3029-38

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 21

MONTH: 08

YEAR: 2006

CRF receptors in the rodent and human cardiovascular systems: species differences. Information

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LANGUAGE: eng

NlmUniqueID: 8008690

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Grant and Affiliation Information for CRF receptors in the rodent and human cardiovascular systems: species differences.

AFFILIATION: Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, PO Box 62, Murtenstrasse 31, CH-3010 Bern, Switzerland.

Country: United States

AGENCY: United States NIDDK

GRANT: DK P01 26741

ACRONYM: DK

MEDLINETA: Peptides

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