CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region.

CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Abstract Text:

Cheryl L Maslen,Darcie Babcock,Jennifer K Redig,Katannya Kapeli,Yassmine M Akkari,Susan B Olson,

CRELD2 is the second member of the CRELD family of proteins. The only other CRELD family member, encoded by CRELD1, is also known as the AVSD2 gene as mutations in CRELD1 are associated with cardiac atrioventricular septal defects (AVSD). Like CRELD1, CRELD2 is ubiquitously expressed during development and by mature tissues. Recently, a specific CRELD2 isoform (CRELD2beta) was implicated as a regulator of alpha4beta2 nicotinic acetylcholine receptor expression, suggesting that the CRELD family has widely diverse biological roles in both developmental events and subsequent cell function. Here we report additional characterization of CRELD2, which was undertaken to further our understanding of this important family. Mapping of CRELD2 by FISH shows that it maps to 22q13 rather than the GenBank reported locus of 22p13. Comparative genomic analysis of upstream sequences shows a discrete region that is highly conserved among diverse species with hallmark features indicative of a promoter region. Functional analysis demonstrates that this region has promoter activity. Consistent with widespread expression of CRELD2, this region is GC-rich and lacks a TATA box. Overall, the highest levels of CRELD2 expression occur in adult endocrine tissues. However, alternative splicing of CRELD2 is extensive with positive identification of several splice variants expressed by most normal fetal and adult tissues. Confirmed splice variants encode 5 different CRELD2 isoforms that differ significantly in composition indicating that CRELD2 function is varied and as yet poorly understood.

CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Publishing Authors By Initials

CL Maslen,D Babcock,JK Redig,K Kapeli,YM Akkari,SB Olson,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

PUBMED ID PMID:

MEDLINE DATE:

CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Gene

VOLUME: 382

Page Numbers: 111-20

Journal Abbreviation: Gene

ISSN: 0378-1119

DAY: 7

MONTH: 07

YEAR: 2006

CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7706761

CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: genetics

Chemical & Substance for Abstract: CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. Information

Substance Name: Extracellular Matrix Proteins

Registry Number: 0

Grant and Affiliation Information for CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region.

AFFILIATION: Department of Medicine, Oregon Health and Science University, Portland Oregon 97239, USA. maslenc@ohsu.edu

Country: Netherlands

AGENCY: United States NCRR

GRANT: 5 M01 RR00334

ACRONYM: RR

MEDLINETA: Gene

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region Related Publications

• A novel alphavirus vaccine encoding prostate-specific membrane antigen elicits potent cellular and humoral immune responses.
• Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway.
• BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect.
• CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region.
• Combination of neuronal signals representing object-centered location and saccade direction in macaque supplementary eye field.
• Comparison of treatment of pyometra with estradiol cypionate or cloprostenol followed by infusion or non-infusion with nitrofurazone.
• Concurrent retrograde ejaculation and hypothyroidism in a dog: Case report.
• Conservation of regional gene expression in mouse and human brain.
• Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expression.
• Detecting disease-causing mutations in the human genome by haplotype matching.
• Effects of a static stretching versus conventional warm-up on power output during wingate cycle performance: 2025: board #95 may 31 2:00 PM - 3:30 PM.
• Genetic and environmental influences on word recognition and spelling deficits as a function of age.
• Genetic determinants of Sindbis virus strain TR339 affecting midgut infection in the mosquito Aedes aegypti.
• Hyperphosphorylation of MEF2A in primary adipocytes correlates with downregulation of human GLUT4 gene promoter activity.
• Identification of a hamster sperm 26-kilodalton dehydrogenase/reductase that is exclusively localized to the mitochondria of the flagellum.
• Impact of experience on the representation of object-centered space in the macaque supplementary eye field.
• Increased lumbar viscoelastic tissue compliance as a function of static passive trunk flexion: 739: may 31 2:45 PM 3:00 PM.
• Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis.
• MEF2C transcription factor controls chondrocyte hypertrophy and bone development.
• Microtubule network is required for insulin signaling through activation of Akt/protein kinase B: evidence that insulin stimulates vesicle docking/fusion but not intracellular mobility.
• Natriuretic peptides and myocardial structure: insights from population genetics.
• Non-infectivity of semen from bulls infected with bovine leukosis virus.
• Patterns of ecstasy-associated hyponatremia in California.
• Repetition suppression in monkey inferotemporal cortex: relation to behavioral priming.
• Review of the role of anticonvulsant prophylaxis following brain injury.
• Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme
• Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma.
• The ras signalling pathway as a target in cancer therapy.
• True hermaphroditism in a wild sheep: A clinical report.
• Web site disseminates information about sun protection program.