CpG islands: their potential as biomarkers for cancer.

CpG islands: their potential as biomarkers for cancer. Research Abstract Details 

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CpG islands: their potential as biomarkers for cancer. Abstract Text:

Huidong Shi,Michael X Wang,Charles W Caldwell,

In general, DNA methylation acts in concert with other epigenetic processes, including histone modifications, chromatin remodeling and microRNAs, to shape the overall chromatin structure of the nucleus and potentially modify its functional state. Aberrant DNA methylation events can occur in a number of human diseases but we are only just beginning to appreciate the scope and magnitude of this process in human health. As one example, in contrast to normal cells, the cancer methylome is characterized by reciprocal hypermethylation of specific regulatory regions of genes along with an overall decrease in the quantity of 5-methylcytosine throughout the remainder of the genome. Currently, near genome-wide technologies are available and have been utilized to examine the extent of DNA methylation in discovery-based studies involving several physiological and disease states. Although early in the process, DNA methylation is being explored as a biomarker to be used in clinical practice for early detection of disease, tumor classification and for predicting disease outcome or recurrence. This perspective focuses on the current and future states of the use of DNA methylation biomarkers in disease diagnosis, prognosis and classification, with a particular emphasis on cancer.

CpG islands: their potential as biomarkers for cancer. Publishing Authors By Initials

H Shi,MX Wang,CW Caldwell,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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MEDLINE DATE:

CpG islands: their potential as biomarkers for cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of molecular diagnostics

VOLUME: 7

Page Numbers: 519-31

Journal Abbreviation: Expert Rev. Mol. Diagn.

ISSN: 1744-8352

DAY: 3

MONTH: Sep

YEAR: 2007

CpG islands: their potential as biomarkers for cancer. Information

Number of References: 110

LANGUAGE: eng

NlmUniqueID: 101120777

CpG islands: their potential as biomarkers for cancer. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: analysis

Chemical & Substance for Abstract: CpG islands: their potential as biomarkers for cancer. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for CpG islands: their potential as biomarkers for cancer.

AFFILIATION: University of Missouri-Columbia, School of Medicine, Department of Pathology and Anatomical Sciences, Columbia, MO 65212, USA. shihu@health.missouri.edu

Country: England

AGENCY: United States NCI

GRANT: CA123565

ACRONYM: CA

MEDLINETA: Expert Rev Mol Diagn

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