CpG Island Hypermethylation of Tumor-Suppressor Genes in H. pylori-Infected Non-Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk.

CpG Island Hypermethylation of Tumor-Suppressor Genes in H. pylori-Infected Non-Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk. Research Abstract Details 

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CpG Island Hypermethylation of Tumor-Suppressor Genes in H. pylori-Infected Non-Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk. Abstract Text:

Mitsuru Kaise,Takuji Yamasaki,Jin Yonezawa,Jun Miwa,Yasuhiko Ohta,Hisao Tajiri,Mitsuru Kaise,Takuji Yamasaki,Jin Yonezawa,Jun Miwa,Yasuhiko Ohta,Hisao Tajiri,

Background and aim: Gastric carcinogenesis involves CpG island hypermethylation (CIHM) of tumor-suppressor genes. Although the CIHM of these genes occurs in non-neoplastic gastric cells, it is unclear whether this epigenetic alteration is linked with aging and/or gastric cancer risk. We investigated this linkage in noncancerous gastric mucosa infected with H. pylori. Subjects and methods: Noncancerous corpus mucosa was endoscopically obtained from H. pylori-positive gastric cancer patients (n = 34), and age-matched H. pylori-positive noncancerous controls (n = 68). Genomic DNA retrieved from the mucosa was subjected to methylation-specific polymerase chain reaction for p16, Ecad, and DAPK genes. Linkage between CIHM and clinicopathologic factors was evaluated. Results: CIHM rates of DAPK, Ecad, and p16 promoters were significantly higher in noncancerous gastric mucosa of gastric cancer patients (91, 88, and 68%, respectively) than in noncancerous controls (71, 53, and 25%, respectively). Multivariate regression analysis showed a significant linkage between CIHM in noncancerous mucosa and coexistence of gastric cancer. Significant linkage between polymorphoneutrophil infiltration and CIHM was observed except for CIHM of p16. No linkage was observed between CIHM and other parameters, including age. High CIHM status (all three tested genes methylated) was associated with an increased risk of gastric cancer, with an odds ratio of 9.8 (95% confidence interval, 3.8-25.3). Conclusions: In a subset of the H. pylori-infected population, CIHM of tumor-suppressor genes in noncancerous gastric mucosa is linked with the risk of gastric cancer and polymorphoneutrophil infiltration, but not aging. CIHM is a potential marker of gastric cancer risk.

CpG Island Hypermethylation of Tumor-Suppressor Genes in H. pylori-Infected Non-Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk. Publishing Authors By Initials

M Kaise,T Yamasaki,J Yonezawa,J Miwa,Y Ohta,H Tajiri,M Kaise,T Yamasaki,J Yonezawa,J Miwa,Y Ohta,H Tajiri,

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CpG Island Hypermethylation of Tumor-Suppressor Genes in H. pylori-Infected Non-Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Helicobacter

VOLUME: 13

Page Numbers: 35-41

Journal Abbreviation: Helicobacter

ISSN: 1083-4389

DAY: 21

MONTH: Feb

YEAR: 2008

CpG Island Hypermethylation of Tumor-Suppressor Genes in H. pylori-Infected Non-Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk. Information

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LANGUAGE: eng

NlmUniqueID: 9605411

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AFFILIATION: Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan.

Country: United States

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MEDLINETA: Helicobacter

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