CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells.

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Abstract Text:

David F LaRosa,Andrew E Gelman,Adeeb H Rahman,Jidong Zhang,Laurence A Turka,Patrick T Walsh,

Toll-like receptor (TLR) ligands are notable for their ability to induce APC maturation, which in turn facilitates optimal T cell mediated immune responses. Toll-like receptor ligands, such as CpG DNA, can also modulate immune responses by blocking the suppressive effects of CD4+CD25+ regulatory T cells (Tregs). Recently, we have demonstrated that CpG DNA, in addition to its actions on APCs and Tregs, can provide direct costimulatory signals to CD4+CD25- T cells. Here we show that this costimulatory effect is sufficient to abrogate suppression by Tregs. These data indicate a previously undefined role for TLR ligands in directly modulating CD4+ T cell responses.

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Publishing Authors By Initials

DF LaRosa,AE Gelman,AH Rahman,J Zhang,LA Turka,PT Walsh,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, regulatory research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, regulatory research

PUBMED ID PMID:

MEDLINE DATE:

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunology letters

VOLUME: 108

Page Numbers: 183-8

Journal Abbreviation: Immunol. Lett.

ISSN: 0165-2478

DAY: 18

MONTH: 01

YEAR: 2007

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7910006

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Regulatory

MESH TERMS: metabolism

Chemical & Substance for Abstract: CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Information

Substance Name: Oligodeoxyribonucleotides

Registry Number: 0

Grant and Affiliation Information for CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells.

AFFILIATION: Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: R01 AI062789-02

ACRONYM: AI

MEDLINETA: Immunol Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells Related Publications

• Activation of NF-kappaB and expression of COX-2 in association with neutrophil infiltration in systemic vascular tissue of women with preeclampsia.
• Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.
• Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.
• Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase.
• Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.
• Catalytic asymmetric methallylation of ketones with an (H8-BINOLate)Ti-based catalyst.
• Characterization of the aminocarboxycyclopropane-forming enzyme CmaC.
• Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases.
• Comparing the physiological and subjective effects of self-administered vs yoked cocaine in humans.
• Coxofemoral luxation in a horse during recovery from general anaesthesia.
• CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells.
• Direct, stereospecific generation of (Z)-disubstituted allylic alcohols.
• Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.
• Highly concentrated catalytic asymmetric allylation of ketones.
• In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum.
• Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection.
• Laser stimulation of the auditory nerve.
• Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection.
• Minimally invasive dentistry: a review and update.
• Nature's inventory of halogenation catalysts: oxidative strategies predominate.
• New antibiotics from bacterial natural products.
• Oceans and human health: Emerging public health risks in the marine environment.
• Opioid drug accidental deaths in the Newcastle area of New South Wales, 1970-1987.
• Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway.
• Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.
• Serum antibody decay in adults following natural respiratory syncytial virus infection.
• Somatostatin therapy for glomus tumors: a report of two cases.
• Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid.
• Targeting adiponectin for cardioprotection.
• The role of RELN in lissencephaly and neuropsychiatric disease.