Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity.

Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity. Research Abstract Details 

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Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity. Abstract Text:

DeLisa Fairweather,Noel R Rose,

Excellent animal models are available for virus-induced and autoimmune heart disease that are remarkably similar to human disease. Developing good animal models for heart disease is crucial because cardiovascular disease is now the leading cause of death in the United States and is estimated to be the leading cause of death in the world by the year 2020. A significant proportion of heart disease in Western populations is associated with inflammation. Myocarditis, or inflammation of the heart muscle, is the major cause of sudden death in young adults. Although most individuals recover from acute myocarditis, genetically susceptible individuals may go on to develop chronic myocarditis and dilated cardiomyopathy (DCM) resulting in congestive heart failure. In this article, we describe a model of autoimmune myocarditis and DCM induced by inoculation with heart-passaged coxsackievirus B3 (CVB3). Intraperitoneal inoculation of susceptible mice with CVB3 induces acute cardiac inflammation from days 7 to 14 postinfection (pi) that progresses to chronic myocarditis and DCM from day 28 to at least 56 pi. The model of CVB3-induced myocarditis presented here allows dissection of the contribution of viral infection and xenobiotics on immune dysregulation and inflammation in the heart. An improved understanding of the interaction between environmental exposures and the development of heart disease represents a clear challenge for immunotoxicologists.

Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity. Publishing Authors By Initials

D Fairweather,NR Rose,

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Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Methods (San Diego, Calif.)

VOLUME: 41

Page Numbers: 118-22

Journal Abbreviation: Methods

ISSN: 1046-2023

DAY: 3

MONTH: Jan

YEAR: 2007

Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9426302

Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity. Keywords Mesh Terms:

KEYWORDS: Xenobiotics

MESH TERMS: toxicity

Chemical & Substance for Abstract: Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity. Information

Substance Name: Xenobiotics

Registry Number: 0

Grant and Affiliation Information for Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity.

AFFILIATION: Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R21 HL065100-03

ACRONYM: HL

MEDLINETA: Methods

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