COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo.

COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. Research Abstract Details 

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COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. Abstract Text:

Eun-Kyung Ahn,Hyoung-Kyu Yoon,Bo Keun Jee,Hye-Jin Ko,Kweon-Haeng Lee,Hyung Jung Kim,Young Lim,

Recent studies have shown that diesel exhaust particles (DEP) have adverse effects on the respiratory tract in vitro and in vivo, related to various pro-inflammatory cytokines and inflammatory mediators. The inflammation induced by the production of cyclooxygenase (COX)-2, an important mediator of inflammation and tumor promotion, and excess eicosanoids may be central to the pathogenesis of DEP-induced airway inflammation. However, the role of COX-2 in the pathogenesis of DEP-induced lung inflammation remains unclear, especially in vivo. In this study, we demonstrated that treatment with 50mug/ml of DEP for 24h induced the expression of the COX-2 gene at both the transcriptional and protein levels, which led to an increase in the release of prostaglandin E(2) (PGE(2)) in A549 cells. In addition, the increased levels of COX-2 and PGE(2) by DEP exposure were significantly suppressed by treatment with 50pg/ml of dexamethasone (Dex). We also showed that exposure to 25mg/kg of DEP induced the expression of the COX-2 protein in mouse lung tissues, and this increased COX-2 expression was attenuated by pretreatment with 5mg/kg of Dex. These findings suggest that COX-2 may play an important role in the pathogenesis of DEP-induced pulmonary inflammation, which is effectively inhibited by glucocorticoid treatment.

COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. Publishing Authors By Initials

EK Ahn,HK Yoon,BK Jee,HJ Ko,KH Lee,HJ Kim,Y Lim,

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COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Toxicology letters

VOLUME: 176

Page Numbers: 178-87

Journal Abbreviation: Toxicol. Lett.

ISSN: 0378-4274

DAY: 4

MONTH: 12

YEAR: 2007

COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. Information

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LANGUAGE: eng

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Grant and Affiliation Information for COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo.

AFFILIATION: Department of Occupational and Environmental Medicine, St. Mary's Hospital, The Catholic University of Korea, Seoul 150-713, Republic of Korea.

Country: Netherlands

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MEDLINETA: Toxicol Lett

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