COX-2 and the kidney.

COX-2 and the kidney. Research Abstract Details 

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COX-2 and the kidney. Abstract Text:

Raymond C Harris,

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain and inflammation. Nonselective NSAIDs inhibit both cyclooxygenase (COX)-1 and COX-2. Nephrotoxicity of nonselective NSAIDs has been well documented. The effects of selective COX-2 inhibitors on renal function and blood pressure are attracting increasing attention. In the kidney, COX-2 is constitutively expressed and is highly regulated in response to alterations in intravascular volume. COX-2 metabolites have been implicated in the mediation of renin release, regulation of sodium excretion, and maintenance of renal blood flow. Similar to nonselective NSAIDs, inhibition of COX-2 may cause edema and modest elevations in blood pressure in a minority of subjects. COX-2 inhibitors may also exacerbate preexisting hypertension or interfere with other antihypertensive drugs. Occasional acute renal failure has also been reported. Caution should be taken when COX-2 inhibitors are prescribed, especially in high-risk patients (including elderly patients and patients with volume depletion).

COX-2 and the kidney. Publishing Authors By Initials

RC Harris,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research

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COX-2 and the kidney. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of cardiovascular pharmacology

VOLUME: 47 Suppl 1

Page Numbers: S37-42

Journal Abbreviation: J. Cardiovasc. Pharmacol.

ISSN: 0160-2446

DAY: 3

MONTH: 12

YEAR: 2006

COX-2 and the kidney. Information

Number of References: 91

LANGUAGE: eng

NlmUniqueID: 7902492

COX-2 and the kidney. Keywords Mesh Terms:

KEYWORDS: Renin

MESH TERMS: metabolism

Chemical & Substance for Abstract: COX-2 and the kidney. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for COX-2 and the kidney.

AFFILIATION: Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. ray.harris@vanderbilt.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK62794

ACRONYM: DK

MEDLINETA: J Cardiovasc Pharmacol

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