Cox-2 and cancer chemoprevention: picking up the pieces.

Cox-2 and cancer chemoprevention: picking up the pieces. Research Abstract Details 

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Cox-2 and cancer chemoprevention: picking up the pieces. Abstract Text:

Monica M Bertagnolli,

Inhibitors of prostaglandin synthesis show great promise as cancer chemopreventive agents, with efficacy demonstrated in randomized clinical trials. Unfortunately, these agents also cause toxicity in susceptible individuals. The recent reports of cardiovascular adverse events in patients treated with selective Cox-2 inhibitors for colorectal adenoma prevention remind us that all therapies carry risks as well as benefits. This article will discuss the biologic rationale for using selective Cox-2 inhibitors in cancer chemoprevention, and outline new avenues of research necessary to allow their successful use in patients at risk for colorectal cancer.

Cox-2 and cancer chemoprevention: picking up the pieces. Publishing Authors By Initials

MM Bertagnolli,

For similar neoplasms research abstracts see: neoplasms research

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Cox-2 and cancer chemoprevention: picking up the pieces. Journal Published:

PUBLICATION TYPE: Review

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 174

Page Numbers: 73-8

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 2007

Cox-2 and cancer chemoprevention: picking up the pieces. Information

Number of References: 41

LANGUAGE: eng

NlmUniqueID: 44671

Cox-2 and cancer chemoprevention: picking up the pieces. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Cox-2 and cancer chemoprevention: picking up the pieces. Information

Substance Name: Cyclooxygenase 2

Registry Number: EC 1.14.99.1

Grant and Affiliation Information for Cox-2 and cancer chemoprevention: picking up the pieces.

AFFILIATION: Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA 02115, USA.

Country: Germany

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MEDLINETA: Recent Results Cancer Res

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