Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol.

Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol. Abstract Text:

B Gallhofer,P Jaanson,A Mittoux,P ,S Lis,S Krieger,B Gallhofer,P Jaanson,A Mittoux,P ,S Lis,S Krieger,B Gallhofer,P Jaanson,A Mittoux,P ,S Lis,S Krieger,

OBJECTIVE: To compare the impact of sertindole and haloperidol on cognitive function in patients suffering from schizophrenia. METHODS: In a 12 week trial, of the 40 patients randomised to treatment, 34 (17 sertindole and 17 haloperidol) were included in the analysis set. Cognitive sub-processes were investigated with the Reaction Time Decomposition (RTD) method and the Wisconsin Card Sorting Test (WCST), at baseline, Week 4 and Week 12. RESULTS: In executive function, i.e. set shifting tasks, sertindole reversed cognitive deficits significantly more than haloperidol. It was demonstrated that this atypical drug improved cognitive processing independently of motor function. Patients receiving sertindole markedly improved on the RTD task at Week 4 and continued to improve (although at a slower rate) at Week 12, those patients receiving haloperidol showed marked impairment at Week 4 with partial recovery by Week 12. CONCLUSION: The study demonstrated two distinct processes of action on cognition between sertindole and haloperidol and the marked beneficial effects of sertindole, particularly in parameters that are regarded as schizophrenia-related cognitive disturbances.

Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol. Publishing Authors By Initials

B Gallhofer,P Jaanson,A Mittoux,P ,S Lis,S Krieger,B Gallhofer,P Jaanson,A Mittoux,P ,S Lis,S Krieger,B Gallhofer,P Jaanson,A Mittoux,P ,S Lis,S Krieger,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacopsychiatry

VOLUME: 40

Page Numbers: 275-86

Journal Abbreviation: Pharmacopsychiatry

ISSN: 0176-3679

DAY: 21

MONTH: Nov

YEAR: 2007

Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8402938

Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol.

AFFILIATION: 1Cognitive Neuroscience Laboratory and Department of Psychiatry, Centre for Psychiatry, Justus-Liebig University, Giessen, Germany.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pharmacopsychiatry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol Related Publications

• 'Racism, ethnicity, identity, and health: UK and US comparative perspectives'.
• A quantitative chemiluminescent method for studying replicative and stress-induced premature senescence in cell cultures.
• Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain.
• An analytical method for determining relative specificities for sequential reactions catalyzed by the same enzyme: Application to the hydrolysis of triacylglycerols by lipases.
• An electrophoretic analysis of the plasma proteins in the aged.
• Comparing individual- and area-based socioeconomic measures for the surveillance of health disparities: A multilevel analysis of Massachusetts births, 1989-1991.
• Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol.
• Demographic and clinical characteristics of chronic prostatitis: prospective comparison of the University of Sciences Malaysia Cohort with the United States National Institutes of Health Cohort.
• Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.
• Echocardiographic reference values in a sample of asymptomatic adult Brazilian population.
• Efficacy of a Combination of Emodepside plus Praziquantel against Larval and Adult Stages of Nematodes (Trichuris muris, Angiostrongylus cantonensis) in Rodents.
• Efficacy of a Combination of Imidacloprid plus Moxidectin against Larval and Adult Stages of Nematodes (Trichuris muris, Angiostrongylus cantonensis) in Rodents.
• Hemicraniectomy for massive cerebral infarction: Evoked potentials as presurgical prognostic factors.
• Immigration and generational trends in body mass index and obesity in the United States: results of the national latino and asian american survey, 2002 2003.
• Improved inverted bubble method for measuring small contact angles at crystal-solution-vapor interfaces.
• Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.
• Looking back but moving forward.
• Mapping and measuring social disparities in premature mortality: the impact of census tract poverty within and across Boston neighborhoods, 1999-2001.
• Methods for recruiting white, black, and hispanic working-class women and men to a study of physical and social hazards at work: the United for Health study.
• Multi-component protein complexes and Golgi membrane trafficking.
• Observations on ethylidene dicoumarin as an anticoagulant, with special reference to puerperal patients.
• Outcome of sleepiness and fatigue scores in obstructive sleep apnea syndrome patients with and without restless legs syndrome after nasal CPAP.
• PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function.
• Perchlorate, Thiocyanate, and Nitrate in Edible Cole Crops (Brassica sp.) Produced in the Lower Colorado River Region.
• Simple repeat evolution includes dramatic primary sequence changes that conserve folding potential.
• The value of albumin-fortified anti-Rh serum for Rh testing.
• Why epidemiologists cannot afford to ignore poverty.
• [Not Available.]
• [Not Available.]
• [Not Available.]