Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty.

Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty. Research Abstract Details 

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Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty. Abstract Text:

Rupak K Banerjee,Ohwon Kwon,Vinayak S Vaidya,Lloyd H Back,

The coupled oxygen transport in the avascular wall of a coronary artery stenosis is studied numerically by solving the convection-diffusion equations. Two geometries replicating stenosis before and after percutaneous transluminal coronary angioplasty (PTCA) are used for the analysis. The results are compared to evaluate the effect of the degree of stenosis on oxygen transport. Important physiological aspects, such as oxygen consumption in the wall, oxygen carried by the hemoglobin, non-Newtonian viscosity of the blood, and supply of oxygen from the vasa vasorum are included. The results show that the [Formula: see text] in the medial region of the arterial wall is approximately 10mmHg. The oxygen flux to the wall increases in the flow acceleration region, whereas it decreases at the flow reattachment zone. Near the location of flow separation, there is a small rise followed by a sharp fall in the oxygen flux. The drop in the oxygen flux to the wall at the point of flow reattachment for pre-PTCA stenosis is four times that for post-PTCA stenosis. The minimum [Formula: see text] in the avascular wall, [Formula: see text] , at this location decreases to approximately 6.0 and 4.2mmHg for post- and pre-PTCA stenosis, respectively. The drop in [Formula: see text] and [Formula: see text] at the point of flow reattachment for pre-PTCA is approximately 2 times that for post-PTCA stenosis. Thus, the present study quantifies the oxygen transport to the arterial wall before and after cardiovascular intervention.

Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty. Publishing Authors By Initials

RK Banerjee,O Kwon,VS Vaidya,LH Back,

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Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomechanics

VOLUME: 41

Page Numbers: 475-9

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ISSN: 0021-9290

DAY: 19

MONTH: 11

YEAR: 2007

Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty.

AFFILIATION: Department of Mechanical Engineering, University of Cincinnati, Cincinnati, OH, USA; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.

Country: United States

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MEDLINETA: J Biomech

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