Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats.

Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats. Research Abstract Details 

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Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats. Abstract Text:

I Poliacek,J Jakus,A ,H ,E ,Z Tomori,

The importance of neurons in the pontine respiratory group for the generation of cough, expiration, and aspiration reflexes was studied on non-decerebrate spontaneously breathing cats under pentobarbitone anesthesia. The dysfunction of neurons in the pontine respiratory group produced by bilateral microinjection of kainic acid (neurotoxin) regularly abolished the cough reflexes evoked by mechanical stimulation of both the tracheobronchial and the laryngopharyngeal mucous membranes and the expiration reflex mechanically induced from the glottis. The aspiration reflex elicited by similar stimulation of the nasopharyngeal region persisted in 73% of tests, however, with a reduced intensity compared to the pre-lesion conditions. The pontine respiratory group seems to be an important source of the facilitatory inputs to the brainstem circuitries that mediate cough, expiration, and aspiration reflexes. Our results indicate the significant role of pons in the multilevel organization of brainstem networks in central integration of the aforementioned reflexes.

Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats. Publishing Authors By Initials

I Poliacek,J Jakus,A ,H ,E ,Z Tomori,

For similar respiratory system: trachea research abstracts see: respiratory system: trachea research

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Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 53

Page Numbers: 155-63

Journal Abbreviation: Physiol Res

ISSN: 0862-8408

DAY: 2

MONTH: 04

YEAR: 2004

Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats. Information

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LANGUAGE: eng

NlmUniqueID: 9112413

Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats. Keywords Mesh Terms:

KEYWORDS: Trachea

MESH TERMS: physiology

Chemical & Substance for Abstract: Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats. Information

Substance Name: Kainic Acid

Registry Number: 487-79-6

Grant and Affiliation Information for Cough, expiration and aspiration reflexes following kainic acid lesions to the pontine respiratory group in anesthetized cats.

AFFILIATION: Department of Biophysics, Jessenius Faculty of Medicine, Comenius University, Malá Hora 4, 037 54 Martin, Slovak Republic. poliacek@jfmed.uniba.sk

Country: Czech Republic

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MEDLINETA: Physiol Res

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