Cost-effectiveness of vitamin therapy for age-related macular degeneration.

Cost-effectiveness of vitamin therapy for age-related macular degeneration. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cost-effectiveness of vitamin therapy for age-related macular degeneration. Abstract Text:

David B Rein,Jinan B Saaddine,John S Wittenborn,Kathleen E Wirth,Thomas J Hoerger,K M Venkat Narayan,Traci Clemons,Stephen W Sorensen,

OBJECTIVE: To determine the cost-effectiveness of vitamin therapy (antioxidants plus zinc) for all indicated patients diagnosed with age-related macular degeneration (AMD). DESIGN: We compared the impacts of vitamin therapy with those of no vitamin therapy using a computerized, stochastic, agent-based model. The model simulated the natural history of AMD and patterns of ophthalmic service use in the United States in a cohort from age 50 years until 100 or death. PARTICIPANTS AND/OR CONTROLS: The model created 20 million simulated individuals. These individuals each received both the intervention (vitamin therapy after diagnosis) and the control (no vitamin therapy). Expected outcomes generated when vitamins were taken after diagnosis were compared with the expected outcomes generated when they were not. METHODS: The model created individuals representative of patients in the U.S. Incidence of early AMD was based on published studies, as was vision loss and response to choroidal neovascularization therapies. Post-incident disease progression was governed by previously unpublished data drawn from the Age-Related Eye Disease Study. MAIN OUTCOME MEASURES: Extent of disease progression, years and severity of visual impairment, cost of ophthalmic care and nursing home services, and quality-adjusted life years (QALYs). Costs and benefits were considered from the health care perspective and discounted using a 3% rate. The analysis was run for 50 years starting in 2003. RESULTS: Compared with no therapy, vitamin therapy yielded a cost-effectiveness ratio of $21,387 per QALY gained and lowered the percentage of patients with AMD who ever developed visual impairment in the better-seeing eye from 7.0% to 5.6%. CONCLUSIONS: Our model demonstrates that vitamin therapy for AMD improves quality of life at a reasonable cost.

Cost-effectiveness of vitamin therapy for age-related macular degeneration. Publishing Authors By Initials

DB Rein,JB Saaddine,JS Wittenborn,KE Wirth,TJ Hoerger,KM Narayan,T Clemons,SW Sorensen,

For similar inorganic chemicals: elements: metals, heavy: zinc research abstracts see: inorganic chemicals: elements: metals, heavy: zinc research

PUBMED ID PMID:

MEDLINE DATE:

Cost-effectiveness of vitamin therapy for age-related macular degeneration. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Ophthalmology

VOLUME: 114

Page Numbers: 1319-26

Journal Abbreviation: Ophthalmology

ISSN: 1549-4713

DAY: 22

MONTH: 02

YEAR: 2007

Cost-effectiveness of vitamin therapy for age-related macular degeneration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802443

Cost-effectiveness of vitamin therapy for age-related macular degeneration. Keywords Mesh Terms:

KEYWORDS: Zinc

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Cost-effectiveness of vitamin therapy for age-related macular degeneration. Information

Substance Name: Zinc

Registry Number: 7440-66-6

Grant and Affiliation Information for Cost-effectiveness of vitamin therapy for age-related macular degeneration.

AFFILIATION: RTI International, Research Triangle Park, North Carolina, USA. drein@rti.org

Country: United States

AGENCY: United States PHS

GRANT: 200-2002-00776

ACRONYM:

MEDLINETA: Ophthalmology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cost-effectiveness of vitamin therapy for age-related macular degeneration Related Publications

• A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System.
• A downloadable three-dimensional virtual model of the visible ear.
• A synthesis of (+)-FR182877, featuring tandem transannular Diels-Alder reactions inspired by a postulated biogenesis.
• A theoretical study of Favorskii reaction stereochemistry. Lessons in torquoselectivity.
• Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI.
• Analysis of milk production traits in early lactation using a reaction norm model with unknown covariates.
• Assertions of "future dangerousness" at federal capital sentencing: rates and correlates of subsequent prison misconduct and violence.
• Assessment and clinical interpretation of polysaccharide antibody responses.
• Capital offenders in Texas prisons: rates, correlates, and an actuarial analysis of violent misconduct.
• Characteristics of participants in a cancer prevention intervention designed for multiethnic workers in small manufacturing worksites.
• Contingency management interventions for HIV-related behaviors.
• Convergent, enantioselective syntheses of guanacastepenes A and E featuring a selective cyclobutane fragmentation.
• Cost-effectiveness of vitamin therapy for age-related macular degeneration.
• Diagnosis and surgical removal of the mandibular impacted third molar.
• Engaging, understanding and including young people in the provision of mental health services.
• Experience with an organ procurement organization-based non-directed living kidney donation programme.
• Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI.
• Methadone maintenance therapy in residential therapeutic community settings: challenges and promise.
• Neutralising antibodies to interferon beta in multiple sclerosis : expert panel report.
• Non malignant gastrointestinal shortcircuit. (Gastrojejunocolic fistula and gastroileostomy).
• OC121: Endometrial polyps, a frequent diagnosis at sonohysterography-do they cause abnormal uterine bleeding?
• Pharmacokinetics of 1,8-cineole, a dietary toxin, in the brushtail possum (Trichosurus vulpecula): significance for feeding.
• Preparation and crystal structure of two bicyclo[1.1.0]butan-2-ones: a hybrid oxyallyl-cyclopropanone motif.
• Primary isolated nodular amyloidosis of the lung.
• Process evaluation results from the Healthy Directions-Small Business study.
• Sample-angle feedback for diffraction anomalous fine-structure spectroscopy.
• Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.
• System analysis and improvement in the process of transplant patient care.
• The Outer membrane protein OmpA of Mannheimia haemolytica A1 is involved in the binding of fibronectin.
• Ventricular-assist devices and total artificial hearts.