Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases.

Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases. Research Abstract Details 

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Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases. Abstract Text:

N A Mayr,W T Yuh,M G Muhonen,D J Fisher,H D Nguyen,J C Ehrhardt,B C Wen,J F Doornbos,D H Hussey,

PURPOSE: To investigate the cost-effectiveness of high-dose MR contrast studies in the management of brain metastases. METHODS: During the phase III clinical trial of high-dose contrast studies (0.3 mmol/kg), 11 of 27 patients were judged by the reviewers to have potential treatment changes based on the additional information provided by the high-dose studies. We retrospectively evaluated how many of these 27 patients had actual treatment changes because of the results of the high-dose study. Using the fee schedule at our institution, the cost-effectiveness was analyzed based on the cost savings from treatment changes and the additional expense of implementing the high-dose studies. RESULTS: A total of 3 craniotomies ($22,800 each) and 2 aggressive courses of radiation therapy ($1122 each) were avoided in 4 patients because of the additional lesions detected by the high-dose studies. This resulted in a treatment cost savings of $70,644. The extra expense for implementing the high-dose study is $9126 for a single injection in all 27 patients, $9295 for 2 separate injections completed in 1 visit in the 11 patients, and $11,154 for 2 separate injections completed in 2 separate visits. The cost savings in management (diagnosis and treatment) therefore ranged from $59,490 to $61,518 for all patients and from $2203 to $2278 per patient. CONCLUSION: Based on our limited data, the high-dose study seems to impact positively on the cost-effectiveness in the management of brain metastases. However, because our study had limitations, our results need to be confirmed with a larger patient population and a more standardized treatment approach and fee schedule.

Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases. Publishing Authors By Initials

NA Mayr,WT Yuh,MG Muhonen,DJ Fisher,HD Nguyen,JC Ehrhardt,BC Wen,JF Doornbos,DH Hussey,

For similar health care economics and organizations: technology assessment, biomedical: technology, high-cost research abstracts see: health care economics and organizations: technology assessment, biomedical: technology, high-cost research

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Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJNR. American journal of neuroradiology

VOLUME: 15

Page Numbers: 1053-61

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: Jun

YEAR: 1994

Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases. Keywords Mesh Terms:

KEYWORDS: Technology, High-Cost

MESH TERMS: economics

Chemical & Substance for Abstract: Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases. Information

Substance Name: Gadolinium

Registry Number: 7440-54-2

Grant and Affiliation Information for Cost-effectiveness of high-dose MR contrast studies in the evaluation of brain metastases.

AFFILIATION: Department of Radiology, University of Iowa College of Medicine, Iowa City.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

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