Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world.

Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world. Research Abstract Details 

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Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world. Abstract Text:

Arthi Vijayaraghavan,Molly Bates Efrusy,Peter D Mazonson,Osman Ebrahim,Ian M Sanne,Christopher C Santas,

OBJECTIVE: Determine the cost-effectiveness of initiating and monitoring highly active antiretroviral therapy (HAART) in developing countries according to developing world versus developed world guidelines. DESIGN: Lifetime Markov model incorporating costs, quality of life, survival, and transmission to sexual contacts. METHODS: We evaluated treating patients with HIV in South Africa according to World Health Organization (WHO) "3 by 5" guidelines (treat CD4 counts 100,000 copies/mL, and monitor CD4 cell counts and viral load every 3 months. RESULTS: Incorporating transmission to partners (excluding indirect costs), treating patients according to developed versus developing world guidelines increased costs by US $11,867 and increased life expectancy by 3.00 quality-adjusted life-years (QALYs), for an incremental cost-effectiveness of $3956 per QALY. Including indirect costs, over the duration of the model, there are net cost savings to the economy of $39.4 billion, with increased direct medical costs of $60.5 billion offset by indirect cost savings of $99.9 billion. CONCLUSIONS: Treating patients with HIV according to developed versus developing world guidelines is highly cost-effective and may result in substantial long-term savings.

Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world. Publishing Authors By Initials

A Vijayaraghavan,MB Efrusy,PD Mazonson,O Ebrahim,IM Sanne,CC Santas,

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Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of acquired immune deficiency syndromes (1

VOLUME: 46

Page Numbers: 91-100

Journal Abbreviation: J. Acquir. Immune Defic. Syndr

ISSN: 1525-4135

DAY: 1

MONTH: Sep

YEAR: 2007

Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world. Information

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LANGUAGE: eng

NlmUniqueID: 100892005

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AFFILIATION: Mosaic Health Care Consultants, Larkspur, CA, USA. vijayaraghavan_arthi@yahoo.com

Country: United States

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MEDLINETA: J Acquir Immune Defic Syndr

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