Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients.

Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients. Research Abstract Details 

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Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients. Abstract Text:

Olaf Penack,Thomas Reinhold,Eckhard Thiel,Igor Wolfgang Blau,Olaf Penack,Thomas Reinhold,Eckhard Thiel,Igor Wolfgang Blau,Olaf Penack,Thomas Reinhold,Eckhard Thiel,Igor Wolfgang Blau,

Background: In a recently reported randomized trial, lowdose intravenous liposomal amphotericin B (L-AmB) reduced the incidence of invasive fungal infections (20.2 vs. 4.6%, p < 0.001) in high-risk patients with hematological malignancies and prolonged neutropenia. Patients and Methods: In the present study, we performed a retrospective cost-benefit analysis of L-AmB prophylaxis from the hospital perspective. Results: Ninety-nine patients were eligible; baseline characteristics were balanced for age, sex, underlying disease, and duration of neutropenia. The mean duration of hospitalization was 42.9 days and 52.3 days in the prophylaxis arm and in patients without antifungal prophylaxis, respectively (p = 0.096). The L-AmB prophylaxis was associated with additional costs of approximately EUR 630 per patient. However, total medication costs (including L-AmB prophylaxis) were EUR 1,219 and EUR 2,815 in patients with L-AmB prophylaxis and in patients in the control arm, respectively (p < 0.001). When involving also costs for medical procedures, the L-AmB prophylaxis reaches a positive net benefit of EUR 1,094 per patient. Conclusions: Our data shows that antifungal prophylaxis, e.g. with L-AmB, can be a safe and effective strategy to reduce the frequency of invasive fungal infections in selected high-risk patients and to obtain significant cost savings for the hospital. Cost-Benefit Assessment of Antifungal Prophylaxis with Liposomal Amphotericin B in Neutropenic Patients Olaf Penacka Thomas Reinholdb Eckhard Thiela Igor Wolfgang Blaua a Department of Hematology, Oncology, and Transfusion Medicine, Charité Campus Benjamin Franklin, bInstitute for Social Medicine, Epidemiology and Health Economics, Charité Campus Mitte, Berlin, Germany.

Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients. Publishing Authors By Initials

O Penack,T Reinhold,E Thiel,IW Blau,O Penack,T Reinhold,E Thiel,IW Blau,O Penack,T Reinhold,E Thiel,IW Blau,

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Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Onkologie

VOLUME: 30

Page Numbers: 621-6

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ISSN: 1423-0240

DAY: 30

MONTH: 11

YEAR: 2007

Cost-benefit assessment of antifungal prophylaxis with liposomal amphotericin B in neutropenic patients. Information

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LANGUAGE: eng

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AFFILIATION: Department of Hematology, Oncology, and Transfusion Medicine, Charité Campus Benjamin Franklin, Berlin, Germany.

Country: Switzerland

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MEDLINETA: Onkologie

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