Cortisol levels and hippocampus volumes in healthy preadolescent children.

Cortisol levels and hippocampus volumes in healthy preadolescent children. Research Abstract Details 

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Cortisol levels and hippocampus volumes in healthy preadolescent children. Abstract Text:

Christoph P Wiedenmayer,Ravi Bansal,George M Anderson,Hongtu Zhu,Jose Amat,Ronald Whiteman,Bradley S Peterson,Christoph P Wiedenmayer,Ravi Bansal,George M Anderson,Hongtu Zhu,Jose Amat,Ronald Whiteman,Bradley S Peterson,

BACKGROUND: Research in animal models has demonstrated that elevated levels of glucocorticoids can inflict damage within the hippocampus. In adult humans, elevated cortisol levels have been associated with reduced hippocampal volumes; however, normative data in children are not available. The objective of this study was to examine possible associations of serum cortisol levels with hippocampal volumes and morphology in healthy children. METHODS: Morning serum cortisol levels and hippocampus magnetic resonance imaging were measured in 17 healthy children (8 girls, 9 boys) between 7 and 12 years of age. RESULTS: Cortisol levels were not associated with total hippocampal volumes; however, with an analysis of surface morphology, significant associations were found for regionally specific portions of the hippocampus. Positive associations were detected for the anterior segment of the hippocampus and inverse associations along the lateral aspects of the hippocampus. CONCLUSIONS: Associations of cortisol levels with regionally specific variations in hippocampal morphology were detected during early development in healthy preadolescent children.

Cortisol levels and hippocampus volumes in healthy preadolescent children. Publishing Authors By Initials

CP Wiedenmayer,R Bansal,GM Anderson,H Zhu,J Amat,R Whiteman,BS Peterson,CP Wiedenmayer,R Bansal,GM Anderson,H Zhu,J Amat,R Whiteman,BS Peterson,

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Cortisol levels and hippocampus volumes in healthy preadolescent children. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 60

Page Numbers: 856-61

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 5

MONTH: 04

YEAR: 2006

Cortisol levels and hippocampus volumes in healthy preadolescent children. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Cortisol levels and hippocampus volumes in healthy preadolescent children. Keywords Mesh Terms:

KEYWORDS: Reference Values

MESH TERMS: blood

Chemical & Substance for Abstract: Cortisol levels and hippocampus volumes in healthy preadolescent children. Information

Substance Name: Hydrocortisone

Registry Number: 50-23-7

Grant and Affiliation Information for Cortisol levels and hippocampus volumes in healthy preadolescent children.

AFFILIATION: Department of Psychiatry, Columbia University, New York, New York 10032, USA. cpw14@columbia.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH59139

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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