Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans.

Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Research Abstract Details 

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Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Abstract Text:

Tara L White,Vandana K Grover,Harriet de Wit,

The current study utilized personality measures thought to relate to noradrenergic and catecholamine function (i.e., sensation seeking, anxiety and aggression) to investigate individual differences in amphetamine-induced increases in cortisol. The goal of the study was to better understand variations in responses to psychostimulants in healthy volunteers. METHOD: A placebo-controlled within-subjects investigation of salivary cortisol responses to oral D-amphetamine (20 mg) was conducted in seventy (N=70) young adults. Personality traits were assessed using the Eysenck Personality Inventory (EPI), Sensation Seeking Scale Form V (SSS-V) and the Multidimensional Personality Questionnaire-Brief Form (MPQ-BF). RESULTS: A more rapid rise in salivary cortisol after d-amphetamine was associated with SSS-V Thrill Seeking (r=-0.32 with time to peak, p<0.05). A greater peak increase in cortisol and a greater recovery after amphetamine was positively associated with MPQ-BF Aggression (r=+0.35, p<0.05; r=+0.38, p<0.05). In contrast, cortisol responses were unrelated to a composite measure of trait anxiety (EPI/MPQ-BF Anxiety Index). CONCLUSIONS: The findings suggest that the personality traits of aggression and thrill seeking are related to cortisol responses to d-amphetamine, raising the possibility that personality may predispose certain individuals to use drugs through a glucocorticoid pathway. The data also suggest a distinction between fear and anxiety, as amphetamine-induced cortisol responses were associated with measures of trait fear but not measures of trait anxiety in the current sample.

Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Publishing Authors By Initials

TL White,VK Grover,H de Wit,

For similar investigative techniques: epidemiologic methods: data collection: questionnaires research abstracts see: investigative techniques: epidemiologic methods: data collection: questionnaires research

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Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 85

Page Numbers: 123-31

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 23

MONTH: 08

YEAR: 2006

Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 367050

Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Keywords Mesh Terms:

KEYWORDS: Questionnaires

MESH TERMS: physiology

Chemical & Substance for Abstract: Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Information

Substance Name: Dextroamphetamine

Registry Number: 51-64-9

Grant and Affiliation Information for Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans.

AFFILIATION: Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA. Tara_White@Brown.edu

Country: United States

AGENCY: United States NIDA

GRANT: T32 DA07255

ACRONYM: DA

MEDLINETA: Pharmacol Biochem Behav

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