Cortisol as an indicator of dopaminergic effects on nicotine craving.

Cortisol as an indicator of dopaminergic effects on nicotine craving. Research Abstract Details 

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Cortisol as an indicator of dopaminergic effects on nicotine craving. Abstract Text:

There is evidence that glucocorticoids mediate the activity of mesencephalic dopaminergic neurons which play an important role in drug-seeking behaviour and that the absence or presence of glucocorticoids determines the intensity of drug self-administration. Moreover, some experiments indicate that corticoids are increased after substance induced dopaminergic stimulation. These findings could imply (a) that differences in basal glucocorticoid levels are associated with differences in craving or (b) that dopamine (DA) induced corticoid release is an indicator of the sensitivity of the dopaminergic system. Therefore, in a sample of 36 male smokers whose DA system was challenged by a DA agonist (lisuride=LIS) and a DA antagonist (fluphenazine=FLU) in a balanced placebo controlled double-blind crossover design, it was investigated if (a) basal cortisol differences and (b) drug induced cortisol responses are related to the amount of nicotine craving after 3.5 h of deprivation from smoking. There were no differences in craving between subjects with high and low basal cortisol levels irrespective of the pharmacological treatment. However, the size of the cortisol change after the DA challenge and deprivation emerged as a good predictor for the amount of craving in that drug condition in which the cortisol response was most pronounced. Findings were interpreted as evidence for the role of cortisol as an indicator of DA sensitivity.

Cortisol as an indicator of dopaminergic effects on nicotine craving. Publishing Authors By Initials

For similar disorders of environmental origin: substance-related disorders: tobacco use disorder research abstracts see: disorders of environmental origin: substance-related disorders: tobacco use disorder research

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Cortisol as an indicator of dopaminergic effects on nicotine craving. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Human psychopharmacology

VOLUME: 18

Page Numbers: 437-46

Journal Abbreviation: Hum Psychopharmacol

ISSN: 0885-6222

DAY: 6

MONTH: Aug

YEAR: 2003

Cortisol as an indicator of dopaminergic effects on nicotine craving. Information

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LANGUAGE: eng

NlmUniqueID: 8702539

Cortisol as an indicator of dopaminergic effects on nicotine craving. Keywords Mesh Terms:

KEYWORDS: Tobacco Use Disorder

MESH TERMS: psychology

Chemical & Substance for Abstract: Cortisol as an indicator of dopaminergic effects on nicotine craving. Information

Substance Name: Prolactin

Registry Number: 9002-62-4

Grant and Affiliation Information for Cortisol as an indicator of dopaminergic effects on nicotine craving.

AFFILIATION: Institute of Psychobiology and Behavioral Medicine, University of Giessen, Otto-Behaghel-Str. 10, Giessen, Germany. martin.reuter@psychol.uni-giessen.de

Country: England

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MEDLINETA: Hum Psychopharmacol

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