Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes.

Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Abstract Text:

Eric M Smith,Mike Gregg,Farhad Hashemi,Liesl Schott,Thomas K Hughes,

1. The aim of this study was to test whether CRF enhanced nuclear factor kappa B (NF-kappaB)-directed gene transcription in leukocytes and the receptor specificity of the effect. Initially, we examined the ability of CRF to modulate an antigen-specific, in vitro antibody response. Since that could be mediated by NF-kappaB transcription factor activity, we tested CRF in a NF-kappaB driven luciferase gene expression reporter assay. 2. CRF enhanced the antigen-specific antibody production in a dose- and time-dependent manner. RAW 264.7 macrophage cells and splenocytes stained by immunohistochemistry were positive for CRF receptors and CRF. Expression of both was up-regulated by mitogen treatment of the splenocytes. CRF also enhanced the NF-kappaB-regulated reporter assay and this could be blocked by a CRF-R1 receptor antagonist. 3. In light of these findings, it seems likely that CRF enhanced the antigen-specific antibody response through the CRF-R1 receptor by elevation of NF-kappaB activity. This study provides further support for the concept that CRF can act as an immunomodulator mediating neuro-immune interactions.

Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Publishing Authors By Initials

EM Smith,M Gregg,F Hashemi,L Schott,TK Hughes,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

PUBMED ID PMID:

MEDLINE DATE:

Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular and molecular neurobiology

VOLUME: 26

Page Numbers: 1021-36

Journal Abbreviation: Cell. Mol. Neurobiol.

ISSN: 0272-4340

DAY: 22

MONTH: 04

YEAR: 2006

Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8200709

Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: drug effects

Chemical & Substance for Abstract: Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Information

Substance Name: Corticotropin-Releasing Hormone

Registry Number: 9015-71-8

Grant and Affiliation Information for Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas, USA. esmith@utmb.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS041495

ACRONYM: NS

MEDLINETA: Cell Mol Neurobiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Corticotropin Releasing Factor CRF activation of NF-kappaB-directed transcription in leukocytes Related Publications

• A practical approach to common behavior problems.
• A sequential design to estimate sensitivity and specificity of a diagnostic or screening test.
• Bone morphogenetic protein-2 stimulates cell recruitment and cementogenesis during early wound healing.
• Can nutritional manipulation enhance immune competence in broiler chickens?
• Contagious Equine Metritis: A review.
• Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes.
• Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo.
• Effects of occlusal loading on ankylosis, bone, and cementum formation during bone morphogenetic protein-2-stimulated periodontal regeneration in vivo.
• Evolutionary relationships of vertebrate NACHT domain-containing proteins.
• Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp.
• Galactosyl transferases of baby hamster kidney (BHK) cells. Characterization of two oligosaccharide products synthesised using bovine asialo submaxillary-gland mucin as acceptor.
• Likelihood-ratio tests for positive selection of human and mouse duplicate genes reveal nonconservative and anomalous properties of widely used methods.
• Low-level otoacoustic emissions may predict susceptibility to noise-induced hearing loss.
• Nautiloid growth rhythms and lunar dynamics (reply).
• Nucleotide substitution at the highly polymorphic K1 locus of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus).
• Oxidative killing of intracellular parasites mediated by macrophages.
• Pregnancy rates and embryo survival following transfer of bovine embryos stored at 4 degrees C.
• Preliminary studies on bovine embryo survival following short-term storage at 4 degrees C.
• Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects.
• Relationships between sensation seeking and use of caffeine, alcohol and cigarettes by New Zealand university students.
• Reproductive Biology of the Mare - Basic and applied aspects O.J. Ginther; 405 pages; Published by Equiservices, 4343 Garfoot Road, Cross Plains, WI 53528, U.S.A. Telephone (608) 798-4026. $51.00 in USA and Canada, $54.00 elsewhere.
• Retrospective.
• SARS: An Emerging Global Microbial Threat.
• Sexual behavior and serum concentrations of reproductive hormones in normal stallions.
• Should criteria for drug dependence differ across drugs?
• The effect of postpartum uterine lavage on foal heat pregnancy rate.
• The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects.
• The etiology of vomiting in infancy and childhood.
• Towards an outcomes-based system.
• What the pediatrician should know about the management of ocular injuries.