Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder.

Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Research Abstract Details 

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Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Abstract Text:

To explore the integrity of the hypothalamic-pituitary-adrenal (HPA) system in major depressive disorder, 12 patients and normal controls matched for sex, age, and body weight received 100 micrograms synthetic human corticotropin-releasing hormone (hCRH) as an i.v. bolus dose. Compared to controls, depressed patients showed an elevation in baseline cortisol and a significant attenuation of net adrenocorticotropin (ACTH) responses, while cortisol secretion in response to hCRH was normal. These abnormalities in HPA axis function and apparent discordances in the interrelationships of ACTH and cortisol baseline and net stimulation responses between depressed patients and normal controls indicate, at least in part, a derangement of the glucocorticoid-dependent negative feedback circuitry and support the hypothesis that HPA hyperactivity in depression involves neurotransmitter-mediated hypothalamic hypersecretion of CRH.

Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Publishing Authors By Initials

For similar endocrine system: endocrine glands: pituitary-adrenal system research abstracts see: endocrine system: endocrine glands: pituitary-adrenal system research

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Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychiatry research

VOLUME: 24

Page Numbers: 25-34

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Apr

YEAR: 1988

Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Keywords Mesh Terms:

KEYWORDS: Pituitary-Adrenal System

MESH TERMS: drug effects

Chemical & Substance for Abstract: Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Information

Substance Name: Corticotropin-Releasing Hormone

Registry Number: 9015-71-8

Grant and Affiliation Information for Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder.

AFFILIATION: Department of Psychiatry, University of Würzburg, FRG.

Country: IRELAND

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MEDLINETA: Psychiatry Res

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