Corticolimbic dysregulation and chronic methamphetamine abuse.

Corticolimbic dysregulation and chronic methamphetamine abuse. Research Abstract Details 

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Corticolimbic dysregulation and chronic methamphetamine abuse. Abstract Text:

Kate Baicy,Edythe D London,

AIMS: This review aims to present and interpret evidence that methamphetamine dependence is associated with disorder of brain function that is required for top-down control of behavior. APPROACH: Presented here are findings from brain imaging studies of human research participants with histories of chronic methamphetamine abuse in the context of functional consequences and implications for treatment of their dependence on methamphetamine. FINDINGS: Brain imaging studies have revealed differences in the brains of research participants who have used methamphetamine chronically and then abstained from taking the drug, compared with healthy control subjects. These abnormalities are prominent in cortical and limbic systems, and include deficits in markers of dopaminergic and serotonergic neurotransmitter systems, differences in glucose metabolism and deficits in gray matter. These abnormalities accompany cognitive deficits, including evidence of impaired inhibitory control. CONCLUSION: Cortical deficits in abstinent methamphetamine abusers can affect a wide range of functions that can be important for success in maintaining drug abstinence. These include but are not limited to modulation of responses to environmental stimuli as well as internal triggers that can lead to craving and relapse. Potential therapies may combine behavioral approaches with medications that can improve cognitive control.

Corticolimbic dysregulation and chronic methamphetamine abuse. Publishing Authors By Initials

K Baicy,ED London,

For similar organic chemicals: amines: ethylamines: phenethylamines: amphetamines: methamphetamine research abstracts see: organic chemicals: amines: ethylamines: phenethylamines: amphetamines: methamphetamine research

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Corticolimbic dysregulation and chronic methamphetamine abuse. Journal Published:

PUBLICATION TYPE: Review

Journal: Addiction (Abingdon, England)

VOLUME: 102 Suppl 1

Page Numbers: 5-15

Journal Abbreviation: Addiction

ISSN: 0965-2140

DAY: 3

MONTH: Apr

YEAR: 2007

Corticolimbic dysregulation and chronic methamphetamine abuse. Information

Number of References: 125

LANGUAGE: eng

NlmUniqueID: 9304118

Corticolimbic dysregulation and chronic methamphetamine abuse. Keywords Mesh Terms:

KEYWORDS: Methamphetamine

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Corticolimbic dysregulation and chronic methamphetamine abuse. Information

Substance Name: Methamphetamine

Registry Number: 537-46-2

Grant and Affiliation Information for Corticolimbic dysregulation and chronic methamphetamine abuse.

AFFILIATION: Department of Psychiatry and Biobehavioral Science, University of California Los Angeles, Los Angeles, CA, USA.

Country: England

AGENCY: United States NCRR

GRANT: M01 RR00865

ACRONYM: RR

MEDLINETA: Addiction

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