Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory.

Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory. Research Abstract Details 

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Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory. Abstract Text:

Joshua C Brumberg,Boris S Gutkin,Joshua C Brumberg,Boris S Gutkin,

Cortical neurons are capable of generating trains of action potentials in response to current injections. These discharges can take different forms, e.g., repetitive firing that adapts during the period of current injection or bursting behaviors. We have used a combined experimental and computational approach to characterize the dynamics leading to action potential responses in single neurons. Specifically we investigated the origin of complex firing patterns in response to sinusoidal current injections. Using a reduced model, the theta-neuron, alongside recordings from cortical pyramidal cells we show that both real and simulated neurons show phase-locking to sine wave stimuli up to a critical frequency, above which period skipping and 1-to-x phase-locking occurs. The locking behavior follows a complex "devil's staircase" phenomena, where locked modes are interleaved with irregular firing. We further show that the critical frequency depends on the time scale of spike generation and on the level of spike frequency adaptation. These results suggest that phase-locking of neuronal responses to complex input patterns can be explained by basic properties of the spike-generating machinery.

Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory. Publishing Authors By Initials

JC Brumberg,BS Gutkin,JC Brumberg,BS Gutkin,

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Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Brain research

VOLUME: 1171

Page Numbers: 122-37

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 20

MONTH: 07

YEAR: 2007

Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory.

AFFILIATION: Department of Psychology, Queens College of the City University of New York, Flushing, NY 11367, USA. joshua.brumberg@qc.cuny.edu

Country: Netherlands

AGENCY: United States NIMH

GRANT: K01 MH01944-01A1

ACRONYM: MH

MEDLINETA: Brain Res

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