Cortical mapping of genotype-phenotype relationships in schizophrenia.

Cortical mapping of genotype-phenotype relationships in schizophrenia. Research Abstract Details 

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Cortical mapping of genotype-phenotype relationships in schizophrenia. Abstract Text:

Carrie E Bearden,Theo G M van Erp,Paul M Thompson,Arthur W Toga,Tyrone D Cannon,

Although schizophrenia is highly heritable, the search for susceptibility genes has been challenging. The "endophenotype" approach is an alternative method for measuring phenotypic variation that may make it easier to identify susceptibility genes in the context of complexly inherited traits. Neuroimaging methods in particular offer a powerful way to bridge the neurobiology of genes and behavior. Such investigations may be further empowered by complementary strategies involving chromosomal abnormalities associated with schizophrenia, which can help to localize causative genes and better understand the genetic complexity of the illness. Here, we illustrate our use of these convergent approaches, with a focus on neuroimaging studies using novel computational brain mapping algorithms, to investigate genetic influences on brain structure in the development of psychosis. These studies provide compelling evidence that specific genetic loci suspected to predispose to schizophrenia may affect quantitative variation in neural indicators underlying the neurobehavioral phenotype, and illustrate how genetic-neuroimaging paradigms can improve our understanding of the pathogenesis of this highly disabling mental illness.

Cortical mapping of genotype-phenotype relationships in schizophrenia. Publishing Authors By Initials

CE Bearden,TG van Erp,PM Thompson,AW Toga,TD Cannon,

For similar mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research abstracts see: mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research

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Cortical mapping of genotype-phenotype relationships in schizophrenia. Journal Published:

PUBLICATION TYPE: Review

Journal: Human brain mapping

VOLUME: 28

Page Numbers: 519-32

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ISSN: 1065-9471

DAY: 3

MONTH: Jun

YEAR: 2007

Cortical mapping of genotype-phenotype relationships in schizophrenia. Information

Number of References: 98

LANGUAGE: eng

NlmUniqueID: 9419065

Cortical mapping of genotype-phenotype relationships in schizophrenia. Keywords Mesh Terms:

KEYWORDS: Schizophrenia

MESH TERMS: physiopathology

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Grant and Affiliation Information for Cortical mapping of genotype-phenotype relationships in schizophrenia.

AFFILIATION: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA. cbearden@mednet.ucla.edu

Country: United States

AGENCY: United States NCRR

GRANT: U54 RR021813

ACRONYM: RR

MEDLINETA: Hum Brain Mapp

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