Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis.

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis. Abstract Text:

Biba R Stanton,Victoria C Williams,P Nigel Leigh,Steven C R Williams,Camilla R V Blain,Vincent P Giampietro,Andrew Simmons,Biba R Stanton,Victoria C Williams,P Nigel Leigh,Steven C R Williams,Camilla R V Blain,Vincent P Giampietro,Andrew Simmons,

The neural correlates of motor execution in Amyotrophic Lateral Sclerosis (ALS) are challenging to investigate due to muscle weakness. Alternatives to traditional motor execution paradigms are therefore of great interest. This study tested the hypothesis that patients with Amyotrophic Lateral Sclerosis (ALS) would show increased cortical activation during motor imagery compared to healthy controls, as seen in studies of motor execution. Functional MRI was used to measure activation during a block design paradigm contrasting imagery of right hand movements against rest in 16 patients with ALS and 17 age-matched healthy controls. Patients with ALS showed reduced activation during motor imagery in the left inferior parietal lobule, and in the anterior cingulate gyrus and medial pre-frontal cortex. This reduction in cortical activation during motor imagery contrasts with the pattern seen during motor execution. This may represent the disruption of normal motor imagery networks by ALS pathology outside the primary motor cortex.

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis. Publishing Authors By Initials

BR Stanton,VC Williams,PN Leigh,SC Williams,CR Blain,VP Giampietro,A Simmons,BR Stanton,VC Williams,PN Leigh,SC Williams,CR Blain,VP Giampietro,A Simmons,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research

VOLUME: 1172

Page Numbers: 145-51

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 3

MONTH: 08

YEAR: 2007

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis.

AFFILIATION: MRC Centre for Neurodegeneration Research and Department of Clinical Neuroscience, King's College London, Institute of Psychiatry PO41, De Crespigny Park, London, UK. b.stanton@iop.kcl.ac.uk

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis Related Publications

• A comparison of the residual effectiveness of certain insecticides against Anopheles quadrimaculatus.
• A summary of the experimental use of DDT as a mosquito larvicide.
• Altered cortical activation during a motor task in ALS. Evidence for involvement of central pathways.
• Assessment of comparative treatment satisfaction with sildenafil citrate and penile injection therapy in patients responding to both.
• Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease.
• Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis.
• Developmental origins of beta-cell failure in type 2 diabetes: the role of epigenetic mechanisms.
• Developmental origins of diabetes: the role of epigenetic mechanisms.
• Direct observations of nursing home care quality: Does care change when observed?
• Dynamic visualization of the developing nervous system of the bullfrog, Rana catesbeiana.
• Herniated intervertebral disk; analysis of 90 cases.
• Human anaphylaxis; report of case due to sulfathiazole sensitivity.
• Identifying menopause in breast cancer patients: considerations and implications.
• Intrathecal morphine dilution.
• Jamming avoidance response of big brown bats in target detection.
• Laboratory evaluation of DDT residual effectiveness against house files, Musca domestica.
• Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels.
• Metamorphosis: essence, appearance, and behavior in the categorization of natural kinds.
• Moniker maladies: when names sabotage success.
• Multiple mechanosensory modalities influence development of auditory function.
• Plasticity of auditory medullary-midbrain connectivity across metamorphic development in the bullfrog, Rana catesbeiana.
• Quality improvement for feeding assistance care in nursing homes.
• Role of metabolic programming in the pathogenesis of beta-cell failure in postnatal life.
• Role of the hydrophilic channels of simian virus 40 T-antigen helicase in DNA replication.
• Single P and As dopants in the Si(001) surface.
• Some epidemiologic and public health aspects of typhus and Rocky Mountain spotted fevers.
• The primary care physician's role in treating chronic kidney disease.
• The second example of anti-Lewis serum found in Australia.
• Using hydraulic head measurements in variable-density ground water flow analyses.
• War on white coats.