Correspondence of low mean shear and high harmonic content in the porcine iliac arteries.

Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. Research Abstract Details 

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Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. Abstract Text:

Heather A Himburg,Morton H Friedman,

BACKGROUND: Temporal variations in shear stress have been suggested to affect endothelial cell biology. To better quantify the range of dynamic shear forces that occur in vivo, the frequency content of shear variations that occur naturally over a cardiac cycle in the iliac arteries was determined. METHOD OF APPROACH: Computational fluid dynamic calculations were performed in six iliac arteries from three juvenile swine. Fourier analysis of the time-varying shear stress computed at the arterial wall was performed to determine the prevalence of shear forces occurring at higher frequencies in these arteries. RESULTS: While most of each artery experienced shear forces predominantly at the frequency of the heart rate, the frequency spectra at certain regions were dominated by shear forces at higher frequencies. Regions whose frequency spectra were dominated by higher harmonics generally experienced lower mean shear stress. The negative correlation between shear and dominant harmonic was significant (p=0.002). CONCLUSIONS: Since lesion development typically occurs in regions experiencing low time-average shear stress, this result suggests that the frequency content of the shear exposure may also be a contributing factor in lesion development. A better understanding of the vascular response to shear components of different frequencies might help rationalize the notion of "disturbed flow" as a hemodynamic entity.

Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. Publishing Authors By Initials

HA Himburg,MH Friedman,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

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Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of biomechanical engineering

VOLUME: 128

Page Numbers: 852-6

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ISSN: 0148-0731

DAY: 3

MONTH: Dec

YEAR: 2006

Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. Information

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LANGUAGE: eng

NlmUniqueID: 7909584

Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: physiology

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Grant and Affiliation Information for Correspondence of low mean shear and high harmonic content in the porcine iliac arteries.

AFFILIATION: Department of Biomedical Engineering, Duke University, Durham, NC, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL050442

ACRONYM: HL

MEDLINETA: J Biomech Eng

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