[Correlation of receptor-mediated apoptosis to cell cycle]

[Correlation of receptor-mediated apoptosis to cell cycle] Research Abstract Details 

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[Correlation of receptor-mediated apoptosis to cell cycle] Abstract Text:

Chang-Yong Yang,Da-Xing Xie,Yi Zhou,Dan Huang,Jian-Ping Gong,

BACKGROUND & OBJECTIVE: Chondriosome-mediated apoptosis is closely related to cell cycle, however, the correlation of receptor-mediated apoptosis to cell cycle progression is unclear yet. This study was to observe the receptor-mediated apoptosis and cell cycle specificity in cultured normal and tumor lymphocytes, and investigate their correlation. METHODS: Exponentially growing human leukemia cell lines Molt-4 and Jurkat were treated with tumor necrosis factor-alpha (TNF-alpha) or Anti-Fas. Peripheral blood lymphocytes (PBLs) from healthy donors were stimulated by phytohemagglutinin (PHA), and further incubated with the presence of TNF-alpha or anti-Fas. Annexin V/PI was used to detect the apoptosis, and API method was used to illustrate the cell cycle specificity of apoptotic cells. RESULTS: Unstimulated PBLs kept blunt to stimulation with TNF-alpha or anti-Fas, and the apoptotic rate was 6%-8%. Molt-4 cells, Jurkat cells, and stimulated PBLs which were treated with TNF-alpha or anti-Fas went to apoptosis, and the apoptosis rates were 15%-28%. Most receptor-mediated apoptosis happened in early G1 phase. CONCLUSION: Receptor-mediated apoptosis is closely related to cell cycle and presents cell cycle specificity.

[Correlation of receptor-mediated apoptosis to cell cycle] Publishing Authors By Initials

CY Yang,DX Xie,Y Zhou,D Huang,JP Gong,

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[Correlation of receptor-mediated apoptosis to cell cycle] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Ai zheng = Aizheng = Chinese journal of cancer

VOLUME: 25

Page Numbers: 576-81

Journal Abbreviation: Ai Zheng

ISSN: 1000-467X

DAY: 11

MONTH: May

YEAR: 2006

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LANGUAGE: chi

NlmUniqueID: 9424852

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AFFILIATION: Cancer Research Institute/Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei,430030, P. R. China.

Country: China

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MEDLINETA: Ai Zheng

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