Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor.

Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Research Abstract Details 

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Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Abstract Text:

Vincent A Bourke,Dawen Zhao,Joseph Gilio,Cheng-Hui Chang,Lan Jiang,Eric W Hahn,Ralph P Mason,

PURPOSE: To investigate the application of pretreatment oxygenation to the AT1 subline of the Dunning R3327 prostate tumor, which is more hypoxic and faster growing than the H1 subline previously studied. METHODS AND MATERIALS: Dunning prostate R3327-AT1 tumors growing on Copenhagen rats were administered 30 Gy of X-ray radiation either with or without oxygen inhalation. Tumor oxygenation was sampled by (19)F nuclear magnetic resonance echo planar imaging relaxometry of the reporter molecule hexafluorobenzene, no more than 24 h before irradiation. RESULTS: Large tumors (>3.0 cm(3)) exhibited significantly greater hypoxic fractions and lower mean partial pressure of oxygen (pO(2)) than their smaller counterparts (<1.5 cm(3)). However, unlike the R3327-HI subline, large AT1 tumors generally did not respond to oxygen inhalation in terms of altered hypoxic fraction or response to irradiation. Although the tumors did not respond to oxygen inhalation, each tumor had a different pO(2), and there was a clear trend between level of oxygenation at time of irradiation and tumor growth delay, with considerably better outcome when mean pO(2) > 10 mm Hg. The comparatively small baseline hypoxic fraction in the group of small tumors was virtually eliminated by breathing oxygen, and the growth rate was significantly reduced for tumors on rats breathing oxygen during irradiation. CONCLUSIONS: These results further validate the usefulness of nuclear magnetic resonance oximetry as a predictor of response to radiation therapy.

Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Publishing Authors By Initials

VA Bourke,D Zhao,J Gilio,CH Chang,L Jiang,EW Hahn,RP Mason,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of radiation oncology, biolo

VOLUME: 67

Page Numbers: 1179-86

Journal Abbreviation: Int. J. Radiat. Oncol. Biol. P

ISSN: 0360-3016

DAY: 15

MONTH: Mar

YEAR: 2007

Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Information

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LANGUAGE: eng

NlmUniqueID: 7603616

Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: radiotherapy

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Grant and Affiliation Information for Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor.

AFFILIATION: Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9058, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: R01 EB002762-05S1

ACRONYM: EB

MEDLINETA: Int J Radiat Oncol Biol Phys

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