Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: A pilot study.

Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: A pilot study. Research Abstract Details 

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Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: A pilot study. Abstract Text:

Tae Iwasawa,Hiroshi Takahashi,Takashi Ogura,Akira Asakura,Toshiyuki Gotoh,Seiichiro Kagei,Jun-Ichi Nishimura,Makoto Obara,Tomio Inoue,Tae Iwasawa,Hiroshi Takahashi,Takashi Ogura,Akira Asakura,Toshiyuki Gotoh,Seiichiro Kagei,Jun-ichi Nishimura,Makoto Obara,Tomio Inoue,

PURPOSE: To evaluate the effect of ventilatory impairment on MR signal intensity of the lung parenchyma. MATERIALS AND METHODS: Subjects were five normal volunteers (age = 30 +/- 7.9 years, mean +/- SD) and 19 male patients with chronic obstructive lung disease (COPD) (mean age = 70.4 +/- 6.5 years). Coronal MR images were obtained over entire lung fields at full inspiration and full expiration with cardiac triggering on a 1.5T system. Changes in the mean lung intensity between the two respiratory states were normalized by each intercept of the linear regression lines of the signal changes, and the slope of the relationship was calculated. Computed tomography (CT) images were also obtained in COPD patients at full inspiration using a multidetector row CT scanner. Attenuation values less than -950 Hounsfield units (HU) (RA-950) represented the percentage of relative lung area on the CT. RESULTS: The mean slope of COPD patients (0.365 +/- 0.074) was less steep than that of the normal subjects (0.570 +/- 0.124, P < 0.001). In COPD patients, the slope correlated significantly with forced expiratory volume in one second (FEV1, r = 0.508, P = 0.026), but not with RA-950. CONCLUSION: In COPD patients, lung signal change measured by MRI correlates with airflow obstruction, but not with volume of the emphysema measured by lung CT. J. Magn. Reson. Imaging 2007. (c) 2007 Wiley-Liss, Inc.

Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: A pilot study. Publishing Authors By Initials

T Iwasawa,H Takahashi,T Ogura,A Asakura,T Gotoh,S Kagei,J Nishimura,M Obara,T Inoue,T Iwasawa,H Takahashi,T Ogura,A Asakura,T Gotoh,S Kagei,J Nishimura,M Obara,T Inoue,

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Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: A pilot study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 26

Page Numbers: 1530-6

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ISSN: 1053-1807

DAY: 10

MONTH: Dec

YEAR: 2007

Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: A pilot study. Information

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LANGUAGE: eng

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AFFILIATION: Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.

Country: United States

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MEDLINETA: J Magn Reson Imaging

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