Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness.

Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Research Abstract Details 

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Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Abstract Text:

Anna Pluzhnikov,Daniel K Nolan,Zhiqiang Tan,Mary Sara McPeek,Carole Ober,

Reproductive fitness is a complex phenotype that is a direct measure of Darwinian selection. Estimation of the genetic contribution to this phenotype in human populations is confounded by within-family correlations of sociocultural, economic, and other nongenetic factors that influence family sizes. Here, we report an intergenerational correlation in reproductive success in the Hutterites, a human population that is relatively homogeneous with respect to sociocultural factors that influence fertility. We introduce an estimator of this correlation that takes into account the presence of multiple parent-offspring pairs from the same nuclear family. Statistical significance of the estimated correlation is assessed by a permutation test that maintains the overall structure of the pedigree. Further, temporal trends in fertility within this population are accounted for. Applying these methods to the S-Leut Hutterites yields a correlation in effective family size of 0.29 between couples and their sons and 0.18 between couples and their daughters, with empirical P<1x10-6 and P=.0041, respectively. Similar results were obtained for completed families (0.31 between couples and their sons and 0.23 between couples and their daughters; empirical P<1x10-6 and P=.00059, respectively). We interpret these results as indicating a significant genetic component to reproductive fitness in the Hutterites.

Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Publishing Authors By Initials

A Pluzhnikov,DK Nolan,Z Tan,MS McPeek,C Ober,

For similar reproductive and urinary physiology: reproduction research abstracts see: reproductive and urinary physiology: reproduction research

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Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of human genetics

VOLUME: 81

Page Numbers: 165-9

Journal Abbreviation: Am. J. Hum. Genet.

ISSN: 0002-9297

DAY: 2

MONTH: 05

YEAR: 2007

Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Information

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LANGUAGE: eng

NlmUniqueID: 370475

Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Keywords Mesh Terms:

KEYWORDS: Reproduction

MESH TERMS: genetics

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Grant and Affiliation Information for Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness.

AFFILIATION: Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.

Country: United States

AGENCY: United States NHGRI

GRANT: HG1645

ACRONYM: HG

MEDLINETA: Am J Hum Genet

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