[Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients]

[Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients] Research Abstract Details 

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[Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients] Abstract Text:

Z Shao,K Chen,G Chen,Y Zhang,T Wang,R Zou,X Zhou,Y Zhou,Y Chu,

OBJECTIVE: To explore factors influencing the effectiveness of immunosuppressive therapy in severe aplastic anemia (SAA). METHODS: The serum levels of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) of 22 SAA patients and 15 normal controls were measured by immunoenzyme assay. RESULTS: Comparing with the normal controls, 40.9% and 63.6% of the SAA patients had higher serum levels of IL-2 (>840ng/L) and of sIL 2R (>320 x 10(3) U/L), respectively. Those who had higher IL-2 levels and higher sIL-2R levels got better responses to cyclosporin A(CsA) and CsA plus antilymphocyte globulin (ALG). CONCLUSION: The serum levels of IL-2 and sIL-2R were correlated with the responsiveness to immunosuppressive therapy in SAA patients and might be useful for directing treatment.

[Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients] Publishing Authors By Initials

Z Shao,K Chen,G Chen,Y Zhang,T Wang,R Zou,X Zhou,Y Zhou,Y Chu,

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[Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 180-2

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: Apr

YEAR: 1997

[Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients] Information

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LANGUAGE: chi

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AFFILIATION: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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