Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer.

Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer. Research Abstract Details 

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Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer. Abstract Text:

The correlation between the molecular size of the surface layer protein (S protein) and both structure and antigenicity of the Campylobacter fetus surface layer (S layer) was investigated in several clinical strains and their spontaneous variants which produce S proteins of molecular weights (MW) different from those of the parents. Only three molecular sizes of the S proteins were observed (98, 127, and 149 kDa) in the parental and variant strains. Immunologically, the 98-kDa protein and the 149-kDa protein but not the 127-kDa protein were cross-reactive. Freeze-etching analysis showed that the 98-kDa S protein formed a hexagonal arrangement with a 24-nm center-to-center space and that the S proteins with larger MW (127 or 149 kDa) formed tetragonal ones with an 8-nm center-to-center space. Thus, the MW changes of the S proteins seen in the variant strains were associated with both morphological and antigenic changes in S layer. These observations support the hypothesis that the pattern and antigenicity of the C. fetus S layer is determined by the particular type of S protein. Furthermore, the presence of the two different S layer patterns on a single bacterial cell indicates that multiple S proteins can be produced and expressed in a single cell.

Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer. Publishing Authors By Initials

For similar natural sciences: chemistry: chemistry, physical: molecular weight research abstracts see: natural sciences: chemistry: chemistry, physical: molecular weight research

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Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Infection and immunity

VOLUME: 59

Page Numbers: 2017-22

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 24

MONTH: Jun

YEAR: 1991

Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer. Information

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LANGUAGE: eng

NlmUniqueID: 246127

Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer. Keywords Mesh Terms:

KEYWORDS: Molecular Weight

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer. Information

Substance Name: S-layer proteins

Registry Number: 0

Grant and Affiliation Information for Correlation between molecular size of the surface array protein and morphology and antigenicity of the Campylobacter fetus S layer.

AFFILIATION: Department of Bacteriology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Country: UNITED STATES

AGENCY: United States NIAID

GRANT: AI 24145

ACRONYM: AI

MEDLINETA: Infect Immun

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