Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14- and CD14+ human normal myeloid precursors.

Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14- and CD14+ human normal myeloid precursors. Research Abstract Details 

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Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14- and CD14+ human normal myeloid precursors. Abstract Text:

M Montanari,C Gemelli,E Tenedini,T Zanocco Marani,T Vignudelli,M Siena,R Zini,S Salati,G Chiossi,E Tagliafico,R Manfredini,A Grande,S Ferrari,M Montanari,C Gemelli,E Tenedini,T Zanocco Marani,T Vignudelli,M Siena,R Zini,S Salati,G Chiossi,E Tagliafico,R Manfredini,A Grande,S Ferrari,

In spite of their apparently restricted differentiation potentiality, hematopoietic precursors are plastic cells able to trans-differentiate from a maturation lineage to another. To better characterize this differentiation plasticity, we purified CD14- and CD14+ myeloid precursors generated by 'in vitro' culture of human CD34+ hematopoietic progenitors. Morphological analysis of the investigated cell populations indicated that, as expected, they consisted of granulocyte and monocyte precursors, respectively. Treatment with differentiation inducers revealed that CD14- cells were bipotent granulo-monocyte precursors, while CD14+ cells appeared univocally committed to a terminal macrophage maturation. Flow cytometry analysis demonstrated that the conversion of granulocyte precursors to the mono-macrophage maturation lineage occurs through a differentiation transition in which the granulocyte-related myeloperoxidase enzyme and the monocyte-specific CD14 antigen are co-expressed. Expression profiling evidenced that the observed trans-differentiation process was accompanied by a remarkable upregulation of the monocyte-related MafB transcription factor.

Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14- and CD14+ human normal myeloid precursors. Publishing Authors By Initials

M Montanari,C Gemelli,E Tenedini,T Zanocco Marani,T Vignudelli,M Siena,R Zini,S Salati,G Chiossi,E Tagliafico,R Manfredini,A Grande,S Ferrari,M Montanari,C Gemelli,E Tenedini,T Zanocco Marani,T Vignudelli,M Siena,R Zini,S Salati,G Chiossi,E Tagliafico,R Manfredini,A Grande,S Ferrari,

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Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14- and CD14+ human normal myeloid precursors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell death and differentiation

VOLUME: 12

Page Numbers: 1588-600

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 10

MONTH: 06

YEAR: 2005

Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14- and CD14+ human normal myeloid precursors. Information

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LANGUAGE: eng

NlmUniqueID: 9437445

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Grant and Affiliation Information for Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14- and CD14+ human normal myeloid precursors.

AFFILIATION: Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, Università di Modena e Reggio Emilia, Modena, Italy.

Country: England

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MEDLINETA: Cell Death Differ

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