Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome.

Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Research Abstract Details 

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Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Abstract Text:

Alexei M C Machado,Tony J Simon,Vy Nguyen,Donna M McDonald-McGinn,Elaine H Zackai,James C Gee,

In this paper, novel methods were used to map the corpus callosum morphology of children with chromosome 22q11.2 deletion syndrome in order to further investigate changes to that structure and to examine their possible effects on cognitive function. The callosal profiles were extracted from the centermost MRI midsagittal slice by supervised thresholding and the structure's boundary and midline were computed automatically. Difference analysis was based on non-rigid registration, in which a template image is warped to conform to the shape of each corpus callosum in the sample. Boundaries and midlines were registered to a template and the results used to determine the average callosal shapes for children with the deletion and for controls. Pointwise registration also enabled the detailed evaluation of callosal curvature, width, area and length. Significant differences between the two groups were found in shape, size and bending angle. Results showed group differences that were concentrated in the anterior part of the structure, more specifically in the rostrum, which was larger and longer in the group with the syndrome. Correlation analyses showed that ventricular enlargement does not fully account for callosal morphology differences in children with the deletion. However, areal measurements did reveal important relationships between changes in callosal morphology and cognitive function. These novel findings reveal intricate relationships between genetic and disease-specific factors in the callosal anatomy and the potential impact of those changes on cognitive functions.

Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Publishing Authors By Initials

AM Machado,TJ Simon,V Nguyen,DM McDonald-McGinn,EH Zackai,JC Gee,

For similar nervous system: neural pathways research abstracts see: nervous system: neural pathways research

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Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research

VOLUME: 1131

Page Numbers: 197-210

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 13

MONTH: 12

YEAR: 2006

Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 45503

Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome. Keywords Mesh Terms:

KEYWORDS: Neural Pathways

MESH TERMS: physiopathology

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Grant and Affiliation Information for Corpus callosum morphology and ventricular size in chromosome 22q11.2 deletion syndrome.

AFFILIATION: Pontifical Catholic University of Minas Gerais, Av. Dom José Gaspar, 500, PPGEE, Belo Horizonte, MG 30535-610, Brazil. alexei@grasp.cis.upenn.edu

Country: Netherlands

AGENCY: United States NICHD

GRANT: R01HD42974

ACRONYM: HD

MEDLINETA: Brain Res

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