Coronary vessel development is dependent on the type III transforming growth factor beta receptor.

Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Research Abstract Details 

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Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Abstract Text:

Leigh A Compton,Dru A Potash,Christopher B Brown,Joey V Barnett,Leigh A Compton,Dru A Potash,Christopher B Brown,Joey V Barnett,

Transforming growth factor (TGF)beta receptor III (TGFbetaR3), or beta-glycan, binds all 3 TGFbeta ligands and inhibin with high affinity but lacks the serine/threonine kinase domain found in the type I and type II receptors (TGFbetaR1, TGFbetaR2). TGFbetaR3 facilitates signaling via TGFbetaR1/TGFbetaR2 but also has been suggested to play a unique and nonredundant role in TGFbeta signaling. Targeted deletion of Tgfbr3 revealed a requirement for Tgfbr3 during development of the coronary vessels. Coronary vasculogenesis is significantly impaired in null mice, with few vessels evident and numerous, persistent blood islands found throughout the epicardium. Tgfbr3-null mice die at embryonic day 14.5, the time when functional coronary vasculature is required for embryo viability. However, in null mice nascent coronary vessels attach to the aorta, form 2 coronary ostia, and initiate smooth muscle recruitment by embryonic day 14. Analysis of earlier developmental stages revealed defects in the epicardium. At embryonic day 13.5, these defects include an irregular and hypercellular epicardium with abundant subepicardial mesenchyme and a thin compact zone myocardium. Tgfbr3-null mice also displayed other defects in coronary development, including dysmorphic and distended vessels along the atrioventricular groove and subepicardial hemorrhage. In null mice, vessels throughout the yolk sac and embryo form and recruit smooth muscle in a pattern indistinguishable from heterozygous or wild-type littermates. These data demonstrate a requirement for Tgfbr3 during coronary vessel development that is essential for embryonic viability.

Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Publishing Authors By Initials

LA Compton,DA Potash,CB Brown,JV Barnett,LA Compton,DA Potash,CB Brown,JV Barnett,

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Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Circulation research

VOLUME: 101

Page Numbers: 784-91

Journal Abbreviation: Circ. Res.

ISSN: 1524-4571

DAY: 17

MONTH: 08

YEAR: 2007

Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 47103

Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Keywords Mesh Terms:

KEYWORDS: Receptors, Transforming Growth Factor be

MESH TERMS: genetics

Chemical & Substance for Abstract: Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Information

Substance Name: betaglycan

Registry Number: 145170-29-2

Grant and Affiliation Information for Coronary vessel development is dependent on the type III transforming growth factor beta receptor.

AFFILIATION: Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6600, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL67105

ACRONYM: HL

MEDLINETA: Circ Res

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