Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic Peptide in hyperinsulinemia.

Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic Peptide in hyperinsulinemia. Research Abstract Details 

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Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic Peptide in hyperinsulinemia. Abstract Text:

Takashi Ashikaga,Mitsuhiro Nishizaki,Hiroyuki Fujii,Kensuke Ihara,Saori Niki,Tadashi Murai,Shingo Maeda,Noriyoshi Yamawake,Yukio Kishi,Mitsuaki Isobe,

Endothelial dysfunction occurs in hyperinsulinemia (HI). Coronary microcirculation responses to vasoactive agents are examined in 57 patients with angiographically normal coronary arteries. Patients were divided into 2 groups, 37 with normoinsulinemia (NI) and 20 with HI based on results of a 75-g oral glucose tolerance test. Epicardial artery vasoactivity in response to acetylcholine chloride is measured to assess endothelial function. Coronary microcirculation function is evaluated by intracoronary administration of 50 microg of adenosine triphosphate, 1 mg of isosorbide dinitrate, and 0.05 mg/kg of atrial natriuretic peptide. Epicardial artery vasoconstriction in response to 100 microg of acetylcholine is mildly reduced in HI (P = .04). Coronary flow reserve in response to adenosine triphosphate in NI is similar to that in HI. In NI, the resting mean (SD) peak velocity in response to isosorbide dinitrate (40.7 [10.9] cm/s) vs atrial natriuretic peptide (39.6 [10.9] cm/s) is similar. In contrast, the resting mean (SD) peak velocity in response to atrial natriuretic peptide (31.3 [9.3] cm/s) vs isosorbide dinitrate (43.5 [10.0] cm/s) in HI is statistically significantly blunted (P < .001). Atrial natriuretic peptide may have a pathologic effect on coronary microcirculation even in mild endothelial dysfunction among patients with HI.

Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic Peptide in hyperinsulinemia. Publishing Authors By Initials

T Ashikaga,M Nishizaki,H Fujii,K Ihara,S Niki,T Murai,S Maeda,N Yamawake,Y Kishi,M Isobe,

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Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic Peptide in hyperinsulinemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cardiovascular pharmacology and therape

VOLUME: 13

Page Numbers: 58-63

Journal Abbreviation: J. Cardiovasc. Pharmacol. Ther

ISSN: 1074-2484

DAY: 21

MONTH: Mar

YEAR: 2008

Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic Peptide in hyperinsulinemia. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic Peptide in hyperinsulinemia.

AFFILIATION: Department of Cardiology, Yokohama Minami Kyosai Hospital, ashikaga-ind@umin.ac.jp.

Country: United States

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MEDLINETA: J Cardiovasc Pharmacol Ther

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