Cornifying Darier disease--a unique variant. I. Report of a case.

Cornifying Darier disease--a unique variant. I. Report of a case. Research Abstract Details 

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Cornifying Darier disease--a unique variant. I. Report of a case. Abstract Text:

A unique variant of Darier disease is described in which a patient was disabled by large, painful, cutaneous horns present on all extremities. The cornified lesions were distinguished by the presence of numerous corps ronds in the basal portion of the greatly hyperkeratotic stratum corneum, hypertrophic dermal villi containing enlarged capillaries, vacuolar dilatation of rough endoplasmic reticulum in sublacunar basal cells, unusually numerous Odland bodies in spinous cells adjacent to lacunae, and persistent attachment of tonofilaments to disrupted desmosomes. Complete separation of tonofilaments from intact desmosomes was not observed. Scanning electron microscopy revealed varied surface morphological appearances of corps ronds and of the epidermal cells covering the elongated dermal villi. The surface cells of cutaneous horns showed little tendency to desquamate.

Cornifying Darier disease--a unique variant. I. Report of a case. Publishing Authors By Initials

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Cornifying Darier disease--a unique variant. I. Report of a case. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 112

Page Numbers: 495-503

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Apr

YEAR: 1976

Cornifying Darier disease--a unique variant. I. Report of a case. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Cornifying Darier disease--a unique variant. I. Report of a case. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: ultrastructure

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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